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Title: MRI compatible head phantom for ultrasound surgery
Authors: Menikou, Georgios 
Dadakova, Tetiana 
Pavlina, Matt 
Bock, Michael 
Damianou, Christakis A. 
Keywords: Brain;MRI;Ultrasound
Category: Electrical Engineering - Electronic Engineering - Information Engineering
Field: Engineering and Technology
Issue Date: 1-Jan-2015
Publisher: Elsevier
Source: Ultrasonics, 2015, vol. 57, no. C, pp. 144-152
Journal: Ultrasonics 
Abstract: Objective: Develop a magnetic resonance imaging (MRI) compatible head phantom with acoustic attenuation closely matched to the human attenuation, and suitable for testing focused ultrasound surgery protocols. Materials and methods: Images from an adult brain CT scan were used to segment the skull bone from adjacent cerebral tissue. The segmented model was manufactured in a 3-D printer using (Acrylonitrile Butadiene Styrene) ABS plastic. The cerebral tissue was mimicked by an agar-evaporated milk-silica gel (2% w/v-25% v/v-1.2% w/v) which was molded inside a skull model. Results: The measured attenuation of the ABS skull was 16 dB/cm MHz. The estimated attenuation coefficient of the gel replicating brain tissue was 0.6 dB/cm MHz. The estimated agar-silica gel's T<inf>1</inf> and T<inf>2</inf> relaxation times in a 1.5 Tesla magnetic field were 852 ms and 66 ms respectively. The effectiveness of the skull to reduce ultrasonic heating was demonstrated using MRI thermometry. Conclusion: Due to growing interest in using MRI guided focused ultrasound (MRgFUS) for treating brain cancer and its application in sonothrombolysis, the proposed head phantom can be utilized as a very useful tool for evaluating ultrasonic protocols, thus minimizing the need for animal models and cadavers.
ISSN: 0041-624X
DOI: 10.1016/j.ultras.2014.11.004
Rights: © 2014 Elsevier B.V.
Type: Article
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