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Title: Functional components of carob fruit: linking the chemical and biological space
Authors: Goulas, Vlasios 
Stylos, Evgenios 
Chatziathanasiadou, Maria V. 
Mavromoustakos, Thomas 
Tzakos, Andreas G. 
Keywords: Cancer;Carob;Diabetes;Diarrhea;Fiber;Hyperlipidemia;Locust bean gum;Omics;Polyphenols;Tannins
Category: Agricultural Biotechnology
Field: Agricultural Sciences
Issue Date: 1-Nov-2016
Publisher: MDPI AG
Source: International Journal of Molecular Sciences, 2016, Volume 17, Issue 11, Article number 1875
DOI: 10.3390/ijms17111875
Abstract: The contribution of natural products to the drug-discovery pipeline has been remarkable since they have served as a rich source for drug development and discovery. Natural products have adapted, during the course of evolution, optimum chemical scaffolds against a wide variety of diseases, including cancer and diabetes. Advances in high-throughput screening assays, assisted by the continuous development on the instrumentation’s capabilities and omics, have resulted in charting a large chemical and biological space of drug-like compounds, originating from natural sources. Herein, we attempt to integrate the information on the chemical composition and the associated biological impact of carob fruit in regards to human health. The beneficial and health-promoting effects of carob along with the clinical trials and the drug formulations derived from carob’s natural components are presented in this review.
ISSN: 16616596
Rights: © 2016 by the authors; licensee MDPI, Basel, Switzerland.
Type: Article
Appears in Collections:Άρθρα/Articles

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