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Title: Feasibility study for removing calcified material using a planar rectangular ultrasound transducer
Authors: Damianou, Christakis A. 
Couppis, Andreas 
Keywords: Atherosclerotic;Plaque;Rabbit;Ultrasound
Category: Materials Engineering
Field: Engineering and Technology
Issue Date: 1-Jun-2016
Publisher: Springer Science+Business Media
Source: Journal of Ultrasound, 2016, vol. 19, no. 2, pp. 115-123
Journal: Journal of Ultrasound 
Abstract: Background: The aim of the proposed study was to conduct a feasibility study using a flat rectangular (3 mm × 10 mm) MRI compatible transducer operating at 5.3 MHz for destroying calcified material in an in vitro model. The proposed method can be used in the future for treating atherosclerosis plaques of the coronary, carotid or peripheral arteries. Methods: The system was tested initially on calcium rods. Another test was performed in a hydroxyapatite–polylactide model. Results: A parametric study was performed where the mass of calcified material removed was studied as a function of intensity, pulse repetition frequency (PRF), duty factor (DF) and presence of bubbles. Conclusions: The amount of calcified material removed is directly related to the intensity, PRF and DF. It was found that the presence of bubbles accelerates the removal of calcified material. In order to ensure that pure mechanical mode ultrasound was used, the protocols were designed so that the temperature does not exceed 1 °C.
ISSN: 1971-3495
DOI: 10.1007/s40477-015-0191-0
Rights: © 2016, Società Italiana di Ultrasonologia in Medicina e Biologia (SIUMB).
Type: Article
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