Please use this identifier to cite or link to this item: https://ktisis.cut.ac.cy/handle/10488/9127
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dc.contributor.authorKapnisis, Konstantinos-
dc.contributor.authorPitsillides, Costas-
dc.contributor.authorProkopi, Marianna-
dc.contributor.authorConstantinides, Georgios-
dc.contributor.authorCristea, Daniel-
dc.contributor.authorMunteanu, Daniel-
dc.contributor.authorBrott, Brigitta-
dc.contributor.authorAnderson, Peter-
dc.contributor.authorLemons, Jack-
dc.contributor.authorAnayiotos, Andreas-
dc.contributor.otherΚαπνίσης, Κωνσταντίνος-
dc.contributor.otherΠιτσιλλίδης, Κώστας-
dc.contributor.otherΠροκόπη, Μαριάννα-
dc.contributor.otherΑναγιωτός, Ανδρέας-
dc.date.accessioned2017-01-18T15:21:21Z-
dc.date.available2017-01-18T15:21:21Z-
dc.date.issued2016-04-01-
dc.identifier.citation14th Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2016; Paphos; Cyprus; 31 March 2016 through 2 April 2016en_US
dc.identifier.isbn978-331932701-3-
dc.identifier.urihttp://ktisis.cut.ac.cy/handle/10488/9127-
dc.description.abstractDespite a considerable clinical and investigative emphasis on the problem of in-stent restenosis (ISR), complications arising from the interaction of stent materials with the surrounding vessel wall as well as from the mechanical forces developing during and after implantation, remain a significant problem. Nanoindentation studies performed on various locations along the stent struts have shown that the hardness of specific stent locations significantly increases after mechanical expansion. The increase in hardness was associated with a reduction of the material‘s ability to dissipate energy in plastic deformations and therefore with an increased vulnerability to fracture and fatigue. It was concluded that the locations of fatigue fractures in stent struts are controlled not only by the geometrically-driven stress concentrations developing during cyclic loading but also by the local material mechanical changes that are imparted on various parts of the stent during the deployment process. Additionally, the project focused on investigating the effect of stent corrosion in an animal model in order to explore a possible link between metal ion release, inflammation and factors thought to initiate ISR. To evaluate the vessel inflammatory response, stents with active corrosion were implanted in mice abdominal aortas and novel in vivo imaging techniques were employed to assess the trafficking and accumulation of fluorescent donor monocytes as well as the proliferation of vascular smooth muscle cells at the implantation site. The in vivo imaging analysis revealed that elevated metal particle contamination, prompted by corroded stents, triggers an inflammatory response and promotes monocyte recruitment with upregulation of MMPs at the site of injury.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.publisherSpringer Verlagen_US
dc.rights© Springer International Publishing Switzerland 2016.en_US
dc.subjectAnimal modelen_US
dc.subjectBiomechanical testingen_US
dc.subjectIn vivo imagingen_US
dc.subjectIn-stent restenosisen_US
dc.subjectStentsen_US
dc.titleMetallic stents: Biomechanical analysis and in vivo investigation of the vessel inflammatory responseen_US
dc.typeConference Papersen_US
dc.doi10.1007/978-3-319-32703-7_212en_US
dc.collaborationCyprus University of Technologyen_US
dc.collaborationTrojantec Ltden_US
dc.collaborationTransilvania University of Brasoven_US
dc.collaborationUniversity of Alabama at Birminghamen_US
dc.subject.categoryClinical Medicineen_US
dc.countryCyprusen_US
dc.countryRomaniaen_US
dc.countryUnited Statesen_US
dc.subject.fieldMedical and Health Sciencesen_US
dc.publicationPeer Revieweden_US
cut.common.academicyear2019-2020en_US
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.languageiso639-1other-
crisitem.author.deptDepartment of Mechanical Engineering and Materials Science and Engineering-
crisitem.author.deptDepartment of Mechanical Engineering and Materials Science and Engineering-
crisitem.author.deptDepartment of Mechanical Engineering and Materials Science and Engineering-
crisitem.author.deptDepartment of Mechanical Engineering and Materials Science and Engineering-
crisitem.author.deptDepartment of Mechanical Engineering and Materials Science and Engineering-
crisitem.author.facultyFaculty of Engineering and Technology-
crisitem.author.facultyFaculty of Engineering and Technology-
crisitem.author.facultyFaculty of Engineering and Technology-
crisitem.author.facultyFaculty of Engineering and Technology-
crisitem.author.facultyFaculty of Engineering and Technology-
crisitem.author.orcid0000-0002-4999-0231-
crisitem.author.orcid0000-0003-4123-3065-
crisitem.author.orcid0000-0003-1979-5176-
crisitem.author.orcid0000-0003-4471-7604-
crisitem.author.parentorgFaculty of Engineering and Technology-
crisitem.author.parentorgFaculty of Engineering and Technology-
crisitem.author.parentorgFaculty of Engineering and Technology-
crisitem.author.parentorgFaculty of Engineering and Technology-
crisitem.author.parentorgFaculty of Engineering and Technology-
Appears in Collections:Δημοσιεύσεις σε συνέδρια/Conference papers
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