Please use this identifier to cite or link to this item: https://ktisis.cut.ac.cy/handle/10488/9094
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dc.contributor.authorKapnisis, Konstantinos-
dc.contributor.authorPitsillides, Costas-
dc.contributor.authorProkopi, Marianna-
dc.contributor.authorLapathitis, George-
dc.contributor.authorKaraiskos, Christos-
dc.contributor.authorEleftheriou, Polyvios-
dc.contributor.authorBrott, Brigitta C.-
dc.contributor.authorAnderson, Peter G.-
dc.contributor.authorLemons, Jack E.-
dc.contributor.authorAnayiotos, Andreas-
dc.contributor.otherΚαπνίσης, Κωνσταντίνος-
dc.contributor.otherΠιτσιλλίδης, Κώστας-
dc.contributor.otherΑναγιωτός, Ανδρέας-
dc.date.accessioned2017-01-18T09:30:25Z-
dc.date.available2017-01-18T09:30:25Z-
dc.date.issued2016-01-01-
dc.identifier.citationJournal of Biomedical Materials Research - Part A, 2016, Volume 104, Issue 1, Pages 227-238en_US
dc.identifier.issn15493296-
dc.identifier.urihttp://ktisis.cut.ac.cy/handle/10488/9094-
dc.description.abstractThe popularity of vascular stents continues to increase for a variety of applications, including coronary, lower limb, renal, carotid, and neurovascular disorders. However, their clinical effectiveness is hindered by numerous postdeployment complications, which may stimulate inflammatory and fibrotic reactions. The purpose of this study was to evaluate the vessel inflammatory response via in vivo imaging in a mouse stent implantation model. Corroded and noncorroded self-expanding miniature nitinol stents were implanted in mice abdominal aortas, and novel in vivo imaging techniques were used to assess trafficking and accumulation of fluorescent donor monocytes as well as cellular proliferation at the implantation site. Monocytes were quantitatively tracked in vivo and found to rapidly clear from circulation within hours after injection. Differences were found between the test groups with respect to the numbers of recruited monocytes and the intensity of the resulting fluorescent signal. Image analysis also revealed a subtle increase in matrix metalloproteinase activity in corroded compared with the normal stented aortas. In conclusion, this study has been successful in developing a murine stent inflammation model and applying novel in vivo imaging tools and methods to monitor the complex biological processes of the host vascular wall response.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Inc.en_US
dc.rights© 2015 Wiley Periodicals, Inc.en_US
dc.subjectIn vivo imagingen_US
dc.subjectInflammationen_US
dc.subjectMouse stent modelen_US
dc.subjectStent corrosionen_US
dc.titleIn vivo monitoring of the inflammatory response in a stented mouse aorta modelen_US
dc.typeArticleen_US
dc.doi10.1002/jbm.a.35560en_US
dc.collaborationCyprus University of Technologyen_US
dc.collaborationTrojantec Ltden_US
dc.collaborationCyprus Institute of Neurology and Geneticsen_US
dc.collaborationUniversity of Alabama at Birminghamen_US
dc.subject.categoryClinical Medicineen_US
dc.journalsSubscription Journalen_US
dc.countryCyprusen_US
dc.countryUnited Statesen_US
dc.subject.fieldMedical and Health Sciencesen_US
dc.publicationPeer Revieweden_US
cut.common.academicyear2019-2020en_US
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.languageiso639-1other-
crisitem.author.deptDepartment of Mechanical Engineering and Materials Science and Engineering-
crisitem.author.deptDepartment of Mechanical Engineering and Materials Science and Engineering-
crisitem.author.deptDepartment of Mechanical Engineering and Materials Science and Engineering-
crisitem.author.deptDepartment of Mechanical Engineering and Materials Science and Engineering-
crisitem.author.deptDepartment of Mechanical Engineering and Materials Science and Engineering-
crisitem.author.facultyFaculty of Engineering and Technology-
crisitem.author.facultyFaculty of Engineering and Technology-
crisitem.author.facultyFaculty of Engineering and Technology-
crisitem.author.facultyFaculty of Engineering and Technology-
crisitem.author.facultyFaculty of Engineering and Technology-
crisitem.author.orcid0000-0002-4999-0231-
crisitem.author.orcid0000-0003-4123-3065-
crisitem.author.parentorgFaculty of Engineering and Technology-
crisitem.author.parentorgFaculty of Engineering and Technology-
crisitem.author.parentorgFaculty of Engineering and Technology-
crisitem.author.parentorgFaculty of Engineering and Technology-
crisitem.author.parentorgFaculty of Engineering and Technology-
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