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Title: Bioassays currently available for evaluating the biological potency of pharmaceuticals in treated wastewater
Authors: Vasquez, Marlen 
Michael, Irene 
Kümmerer, Klaus 
Fatta-Kassinos, Despo 
Major Field of Science: Natural Sciences
Field Category: Earth and Related Environmental Sciences
Keywords: Effect-directed bioassay;Pharmaceutical;Toxicity;Wastewater reuse
Issue Date: 1-Jan-2016
Source: Handbook of Environmental Chemistry, 2016, vol. 44, pp. 49-80
Volume: 44
Start page: 49
End page: 80
Journal: Handbook of Environmental Chemistry 
Abstract: Water deprivation with regard to quantity and quality is one of the most important environmental problems of the century. The increasing demand of water resources puts pressure on the utilization of alternative sources such as treated wastewater. In the context of "reduce, reuse, and recycle," the inclusion of treated wastewater in the water cycle seems a promising practice for water management. The lack of general acceptance of stakeholders and public, however, still hinders the widespread application of wastewater reuse. A reason for this is, among others, the presence of contaminants of emerging concern in treated wastewater. This has led to an increased concern about direct and indirect effects to the environment and possible implications to human health. The development and application of bioassays able to identify and quantify the biological potency of treated wastewater is an ongoing research effort, especially when taking into consideration that a plethora of contaminants exist and interact in this complex matrix. This chapter summarizes available literature regarding the sensitivity of currently applied bioassays for assessing biological effects of treated wastewater and their correlation with chemical analysis. The focus is on pharmaceuticals since they represent one of the major groups of contaminants of emerging concern with many unanswered questions currently in place.
ISSN: 1867-979X
DOI: 10.1007/698-2015-417
Rights: © Springer Nature
Type: Article
Affiliation : Cyprus University of Technology 
Nireas-International Water Research Center 
University of Cyprus 
Leuphana University Lüneburg 
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