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Title: The association of vitamin D with allergy and lung function in asthmatic and healthy adolescents
Authors: Kolokotroni, Ourania 
Yiallouros, Panagiotis
Papadopoulou, A.
Kouta, Christiana 
Raftopoulos, Vasileios
Nicolaidou, P.
Middleton, Nicos 
Keywords: Vitamin D;Asthma;Allergy;Lung function;Public health
Category: Clinical Medicine
Field: Medical and Health Sciences
Issue Date: 2015
Publisher: The Oxford University Press
Source: The European Journal of Public Health, Volume 25, Supplement 3, Pages 238 2015
Abstract: Background.Hypovitaminosis D is becoming an important public health problem everywhere, even in sunny parts of Europe. The role of vitamin D in skeletal disease is well-known but evidence suggests it might also be implicated in asthma and allergies.Objectives: To investigate the association of Vitamin D with allergic sensitization and lung function in asthmatic and non-asthmatic individuals.Methods.All reporting current wheezing on the ISAAC questionnaire among 538 4 16-18 year old Cypriot adolescents (65% response) were grouped into active asthmatics (CWA), if also reported asthma diagnosis (N = 69), and current wheezers only (CWO, N = 121). Controls were sampled amongst Never Wheezers/ Never Asthmatics (NWNA, N = 671, 75% response). Measures included serum 25(OH)D, lung function using spirometry (FEV1 and FVC) and skin prick testing to 8 aeroallergens. The association of vitamin D with study outcomes in each group was investigated in regression models.Results Vitamin D deficiency (< 20 ng/ml) and insufficiency (<30 ng/ml) were associated with allergic sensitization among wheezers. Those with vitamin D insufficiency were almost 4-times more likely to be sensitized to at least one allergen (OR 3.83, 95% CI = 1.23-11.96) after adjusting for seasonality and family history of allergy. Prevalence of polysensitization (positive >3 allergens) appeared 3–4 times higher among wheezers and NWNA with vitamin D insufficiency, even though associations were short of statistical significance due to the small number of participants in the vitamin D sufficiency range (only one in 10). In contrast, only a weak correlation was observed between Vitamin D and FVC in CWA (>0.27, p = 0.09) while no association was observed with lung function measures in the other groups.Conclusions.The results suggest a possible link between vitamin D and allergic sensitization against a background of mixed findings of mainly cross-sectional and only two prospective studies in the literature.
Rights: © The Author 2015.
Type: Article
Appears in Collections:Άρθρα/Articles

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