Please use this identifier to cite or link to this item: https://ktisis.cut.ac.cy/handle/10488/8633
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dc.contributor.authorKolokotroni, Ourania-
dc.contributor.authorMiddleton, Nicos-
dc.contributor.authorKouta, Christiana-
dc.contributor.authorRaftopoulos, Vasilios-
dc.contributor.authorYiallouros, Panayiotis K.-
dc.date.accessioned2016-07-11T11:01:42Z-
dc.date.available2016-07-11T11:01:42Z-
dc.date.issued2015-
dc.identifier.citationMini-Reviews in Medicinal Chemistry, vol. 15, no. 11, pp. 881-899.en_US
dc.identifier.issn1389-5575-
dc.description.abstractDuring the last decades, vitamin D deficiency has re-emerged worldwide affecting not only population’s bone health, but also several other conditions including asthma and allergies. Increasing number of published epidemiological studies in the last seven years have examined the role of vitamin D deficiency in childhood in several outcomes including asthma diagnosis, asthma disease severity, allergic sensitization and atopy. This review presents evidence on this association from a systematic search in the literature of all available observational studies and their limitations. A total of 33 studies were identified: 3 prospective, 16 case-control and 14 cross-sectional studies. Overall, most of the case-control studies tend to report that asthmatics have lower vitamin D levels/status as compared to healthy children, although most of these studies are mainly descriptive in nature and tend to provide only crude, unadjusted comparisons. Studies that investigated the association of vitamin D with the prevalence, development and/or severity of asthma gave mixed findings, with the exception of studies that focused on vitamin D and severity of asthma which suggest a positive association of vitamin D levels with better asthma control, reduced use of asthma medication, fewer asthma exacerbations and lower utilisation of health care facilities for urgent treatment. Insufficient evidence also exists for the association of inadequate vitamin D status with higher risk of atopic sensitization. The lack of adequate number of prospective studies, the variable definitions for case ascertainment, the wide age range of the participants, and commonly the inadequate control for confounders make inferences difficult. Future studies are needed with a prospective design and repeated measurements of vitamin D to provide critical information on the timing and dosage of future vitamin D supplementation interventions.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.publisherBentham Scienceen
dc.relation.ispartofMini-Reviews in Medicinal Chemistryen_US
dc.rights© Bentham Scienceen_US
dc.subjectAsthmaen_US
dc.subjectAtopyen_US
dc.subjectChildrenen_US
dc.subjectEpidemiologyen_US
dc.subjectReviewen_US
dc.subjectVitamin D.en_US
dc.titleAssociation of serum vitamin D with asthma and atopy in childhood: review of epidemiological observational studiesen_US
dc.typeArticleen_US
dc.collaborationCyprus University of Technologyen_US
dc.subject.categoryClinical Medicineen_US
dc.journalsSubscriptionen_US
dc.countryCyprusen_US
dc.subject.fieldMedical and Health Sciencesen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.2174/1389557515666150519105541en_US
dc.dept.handle123456789/118en
dc.relation.issue11en_US
dc.relation.volume15en_US
cut.common.academicyear2015-2016en_US
dc.identifier.spage881en_US
dc.identifier.epage889en_US
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.openairetypearticle-
item.languageiso639-1en-
item.cerifentitytypePublications-
crisitem.author.deptDepartment of Nursing-
crisitem.author.deptDepartment of Nursing-
crisitem.author.deptDepartment of Nursing-
crisitem.author.deptCyprus International Institute for Environmental and Public Health-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.orcid0000-0001-6358-8591-
crisitem.author.orcid0000-0002-2079-638X-
crisitem.author.orcid0000-0003-1042-642X-
crisitem.author.orcid0000-0002-8339-9285-
crisitem.author.parentorgFaculty of Health Sciences-
crisitem.author.parentorgFaculty of Health Sciences-
crisitem.author.parentorgFaculty of Health Sciences-
crisitem.author.parentorgFaculty of Health Sciences-
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