Please use this identifier to cite or link to this item:
Title: Association of serum vitamin D with asthma and atopy in childhood: review of epidemiological observational studies
Authors: Kolokotroni, Ourania 
Middleton, Nicos 
Kouta, Christiana 
Raftopoulos, Vasilios 
Yiallouros, Panayiotis K
Keywords: Asthma;Atopy;Children;Epidemiology;Review;Vitamin D.
Category: Clinical Medicine
Field: Medical and Health Sciences
Issue Date: 2015
Publisher: Bentham Science
Source: Mini-Reviews in Medicinal Chemistry, Volume 15, Issue 11, Pages 881-899, 2015
Abstract: During the last decades, vitamin D deficiency has re-emerged worldwide affecting not only population’s bone health, but also several other conditions including asthma and allergies. Increasing number of published epidemiological studies in the last seven years have examined the role of vitamin D deficiency in childhood in several outcomes including asthma diagnosis, asthma disease severity, allergic sensitization and atopy. This review presents evidence on this association from a systematic search in the literature of all available observational studies and their limitations. A total of 33 studies were identified: 3 prospective, 16 case-control and 14 cross-sectional studies. Overall, most of the case-control studies tend to report that asthmatics have lower vitamin D levels/status as compared to healthy children, although most of these studies are mainly descriptive in nature and tend to provide only crude, unadjusted comparisons. Studies that investigated the association of vitamin D with the prevalence, development and/or severity of asthma gave mixed findings, with the exception of studies that focused on vitamin D and severity of asthma which suggest a positive association of vitamin D levels with better asthma control, reduced use of asthma medication, fewer asthma exacerbations and lower utilisation of health care facilities for urgent treatment. Insufficient evidence also exists for the association of inadequate vitamin D status with higher risk of atopic sensitization. The lack of adequate number of prospective studies, the variable definitions for case ascertainment, the wide age range of the participants, and commonly the inadequate control for confounders make inferences difficult. Future studies are needed with a prospective design and repeated measurements of vitamin D to provide critical information on the timing and dosage of future vitamin D supplementation interventions.
ISSN: 1389-5575
DOI: 10.2174/1389557515666150519105541
Rights: © 2016 Bentham Science
Type: Article
Appears in Collections:Άρθρα/Articles

Show full item record

Citations 50

checked on Apr 20, 2019


checked on Sep 14, 2019

Page view(s)

Last Week
Last month
checked on Sep 15, 2019

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.