Please use this identifier to cite or link to this item: https://ktisis.cut.ac.cy/handle/10488/7517
DC FieldValueLanguage
dc.contributor.authorChakraverty, Ronjon K.-
dc.contributor.authorCôté, Daniel-
dc.contributor.authorPitsillides, Costas-
dc.date.accessioned2013-03-04T11:07:54Zen
dc.date.accessioned2013-05-17T05:22:55Z-
dc.date.accessioned2015-12-02T10:12:53Z-
dc.date.available2013-03-04T11:07:54Zen
dc.date.available2013-05-17T05:22:55Z-
dc.date.available2015-12-02T10:12:53Z-
dc.date.issued2006-07-31-
dc.identifier.citationJournal of Experimental Medicine, 2006,vol. 203, no. 8, pp. 2021-2031en_US
dc.identifier.issn1540-9538-
dc.description.abstractTransfer of T cells to freshly irradiated allogeneic recipients leads to their rapid recruitment to nonlymphoid tissues, where they induce graft-versus-host disease (GVHD). In contrast, when donor T cells are transferred to established mixed chimeras (MCs), GVHD is not induced despite a robust graft-versus-host (GVH) reaction that eliminates normal and malignant host hematopoietic cells. We demonstrate here that donor GVH-reactive T cells transferred to MCs or freshly irradiated mice undergo similar expansion and activation, with similar up-regulation of homing molecules required for entry to nonlymphoid tissues. Using dynamic two-photon in vivo microscopy, we show that these activated T cells do not enter GVHD target tissues in established MCs, contrary to the dogma that activated T cells inevitably traffic to nonlymphoid tissues. Instead, we show that the presence of inflammation within a nonlymphoid tissue is a prerequisite for the trafficking of activated T cells to that site. Our studies help to explain the paradox whereby GVH-reactive T cells can mediate graft-versus-leukemia responses without inducing GVHD in established MCsen_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.publisherRockefeller University Pressen
dc.relation.ispartofJournal of Experimental Medicineen_US
dc.rights© The Rockefeller University Pressen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectT cellsen_US
dc.subjectMiceen_US
dc.subjectAnimal experimentationen_US
dc.subjectAnimal tissueen_US
dc.subjectgraft versus host reactionen_US
dc.subjectGraft versus host diseaseen_US
dc.subjectInflammationen_US
dc.titleAn inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissuesen_US
dc.typeArticleen_US
dc.affiliationMassachusetts General Hospitalen
dc.collaborationWellman Center for Photomedicineen_US
dc.collaborationTransplantation Biology Research Centeren_US
dc.subject.categoryBasic Medicineen_US
dc.journalsSubscriptionen_US
dc.countryCyprusen_US
dc.subject.fieldMedical and Health Sciencesen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.1084/jem.20060376en_US
dc.identifier.pmid16880259-
dc.dept.handle123456789/54en
dc.relation.issue8en_US
dc.relation.volume203en_US
cut.common.academicyear2006-2007en_US
dc.identifier.spage2021en_US
dc.identifier.epage2031en_US
item.languageiso639-1en-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairetypearticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.fulltextNo Fulltext-
crisitem.journal.journalissn1540-9538-
crisitem.journal.publisherRockefeller University Press-
crisitem.author.deptDepartment of Mechanical Engineering and Materials Science and Engineering-
crisitem.author.facultyFaculty of Engineering and Technology-
crisitem.author.parentorgFaculty of Engineering and Technology-
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