Please use this identifier to cite or link to this item: https://ktisis.cut.ac.cy/handle/10488/7517
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dc.contributor.authorChakraverty, Ronjon K.en
dc.contributor.authorCôté, Danielen
dc.contributor.authorPitsillides, Costas-
dc.contributor.otherΠιτσιλλίδης, Κώστας-
dc.date.accessioned2013-03-04T11:07:54Zen
dc.date.accessioned2013-05-17T05:22:55Z-
dc.date.accessioned2015-12-02T10:12:53Z-
dc.date.available2013-03-04T11:07:54Zen
dc.date.available2013-05-17T05:22:55Z-
dc.date.available2015-12-02T10:12:53Z-
dc.date.issued2006en
dc.identifier.citationJournal of experimental medicine, 2006, Volume 203, Issue 8, Pages 2021-2031en
dc.identifier.issn0022-1007 (print)en
dc.identifier.issn1540-9538 (online)en
dc.identifier.urihttp://ktisis.cut.ac.cy/handle/10488/7517en
dc.description.abstractTransfer of T cells to freshly irradiated allogeneic recipients leads to their rapid recruitment to nonlymphoid tissues, where they induce graft-versus-host disease (GVHD). In contrast, when donor T cells are transferred to established mixed chimeras (MCs), GVHD is not induced despite a robust graft-versus-host (GVH) reaction that eliminates normal and malignant host hematopoietic cells. We demonstrate here that donor GVH-reactive T cells transferred to MCs or freshly irradiated mice undergo similar expansion and activation, with similar up-regulation of homing molecules required for entry to nonlymphoid tissues. Using dynamic two-photon in vivo microscopy, we show that these activated T cells do not enter GVHD target tissues in established MCs, contrary to the dogma that activated T cells inevitably traffic to nonlymphoid tissues. Instead, we show that the presence of inflammation within a nonlymphoid tissue is a prerequisite for the trafficking of activated T cells to that site. Our studies help to explain the paradox whereby GVH-reactive T cells can mediate graft-versus-leukemia responses without inducing GVHD in established MCsen
dc.language.isoenen
dc.publisherRockefeller University Pressen
dc.rightsJEM © The Rockefeller University Pressen
dc.subjectT cellsen
dc.subjectMiceen
dc.subjectAnimal experimentationen
dc.subjectAnimal tissueen
dc.subjectgraft versus host reactionen
dc.subjectGraft versus host diseaseen
dc.subjectInflammationen
dc.titleAn inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissuesen
dc.typeArticleen
dc.affiliationMassachusetts General Hospitalen
dc.identifier.doi10.1084/jem.20060376en
dc.identifier.pmid16880259-
dc.dept.handle123456789/54en
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.languageiso639-1other-
crisitem.author.deptDepartment of Mechanical Engineering and Materials Science and Engineering-
crisitem.author.facultyFaculty of Engineering and Technology-
crisitem.author.parentorgFaculty of Engineering and Technology-
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