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Title: Effect of Head Posture on the Healthy Human Carotid Bifurcation Hemodynamics
Authors: Aristokleous, Nicolas 
Khozeymeh, Mohammad Iman 
Anayiotos, Andreas 
Major Field of Science: Engineering and Technology
Field Category: Medical Engineering
Keywords: Atherosclerosis;Geometry;Hemodynamics;Carotid artery
Issue Date: 10-Nov-2012
Source: Medical & Biological Engineering & Computing, 2012, vol. 51, pp. 207–218
Volume: 51
Start page: 207
End page: 218
Journal: Medical & Biological Engineering & Computing 
Abstract: Head and neck postures may cause morphology changes to the geometry of the carotid bifurcation (CB) that alter the low and oscillating wall shear stress (WSS) regions previously reported as important in the development of atherosclerosis. Here the right and left CB were imaged by MRI in two healthy subjects in the neutral head posture with the subject in the supine position and in two other head postures with the subject in the prone position: (1) rightward rotation up to 80°, and (2) leftward rotation up to 80°. Image-based computational models were constructed to investigate the effect of posture on arterial geometry and local hemodynamics. The area exposure to unfavorable hemodynamics, based on thresholds set for oscillatory shear index (OSI), WSS and relative residence time, was used to quantify the hemodynamic impact on the wall. Torsion of the head was found to: (1) cause notable changes in the bifurcation and internal carotid artery angles and, in most cases, on cross-sectional area ratios for common, internal and external carotid artery, (2) change the spatial distribution of wall regions exposed to unfavorable hemodynamics, and (3) cause a marked change in the hemodynamic burden on the wall when the OSI was considered. These findings suggest that head posture may be associated with the genesis and development of atherosclerotic disease as well as complications in stenotic and stented vessels.
ISSN: 1741-0444
DOI: 10.1007/s11517-012-0985-6
Rights: © International Federation for Medical and Biological Engineering 2012
Type: Article
Affiliation : Institute of Applied and Computational Mathematics 
Cyprus University of Technology 
Democritus University of Thrace 
Ayios Therissos Medical Diagnostic Center 
University of Cyprus 
University of Alabama at Birmingham 
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