Please use this identifier to cite or link to this item: https://ktisis.cut.ac.cy/handle/10488/6999
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dc.contributor.authorPapathanassoglou, Elizabeth-
dc.contributor.authorChristou, Helen-
dc.contributor.authorConnors, Jean Marie-
dc.contributor.otherΠαπαθανάσογλου, Ελισάβετ-
dc.date.accessioned2013-02-13T13:42:22Zen
dc.date.accessioned2013-05-16T08:36:44Z-
dc.date.accessioned2015-12-02T09:40:42Z-
dc.date.available2013-02-13T13:42:22Zen
dc.date.available2013-05-16T08:36:44Z-
dc.date.available2015-12-02T09:40:42Z-
dc.date.issued2001-02-
dc.identifier.citationJournal of Clinical Endocrinology and Metabolism, 2001, vol. 86, no. 2, pp. 935-938en_US
dc.identifier.issn0021-972X-
dc.description.abstractThe insulin-like growth factor (IGF) system is the dominant endocrine regulator of fetal growth, whereas insulin has a permissive role. Although a role for leptin in fetal growth has been suggested recently, the mechanism by which leptin may be related to fetal growth is not known; but leptin may interact with the IGF system in utero as it does in the extrauterine life. In the context of a hospital-based case control study, we collected anthropometric and demographic data and measured serum leptin, IGF-I, IGF-II, insulin, cortisol, and IGF binding protein 3 concentrations in 142 cord blood samples from full-term deliveries. Cord leptin, IGF-I, and insulin levels correlated positively with birth weight (r = 0.46, r = 0.41, and r = 0.21, respectively, P < 0.01) by univariate analysis and were significantly higher in large-for-gestational-age (LGA) infants, compared with appropriate-for-gestational-age (AGA) infants. Cord leptin concentrations correlated with insulin levels (r = 0.36, P<0.01) but not with IGF-I levels (r = 0.20). Multiple linear and logistic regression analysis demonstrated an independent positive relationship of both leptin and IGF-I with birth weight and AGA/LGA status. The positive association of leptin levels with birth weight and AGA/LGA status cannot be attributed to IGF-I. This suggests the existence of alternative mechanisms underlying leptin's associations with fetal growth that should be further exploreden_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.publisherThe Endocrine Societyen
dc.relation.ispartofJournal of Clinical Endocrinology and Metabolismen_US
dc.rights© Oxford University Pressen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectEndocrinologyen_US
dc.subjectMetabolismen_US
dc.subjectInsulinen_US
dc.subjectLeptinen_US
dc.subjectFetus--Developmenten_US
dc.subjectHydrocortisoneen_US
dc.subjectBirth weighten_US
dc.titleCord blood leptin and insulin-like growth factor levels are independent predictors of fetal growthen_US
dc.typeArticleen_US
dc.affiliationBeth Israel Deaconess Medical Centeren
dc.collaborationHarvard Medical Schoolen_US
dc.subject.categoryMEDICAL AND HEALTH SCIENCESen_US
dc.journalsOpen Accessen_US
dc.countryCyprusen_US
dc.subject.fieldMedical and Health Sciencesen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.1210/jc.86.2.935en_US
dc.dept.handle123456789/54en
dc.relation.issue2en_US
dc.relation.volume86en_US
cut.common.academicyear2000-2001en_US
dc.identifier.spage935en_US
dc.identifier.epage938en_US
item.languageiso639-1en-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairetypearticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.fulltextNo Fulltext-
crisitem.journal.journalissn1945-7197-
crisitem.journal.publisherOxford University Press-
crisitem.author.deptDepartment of Nursing-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.orcid0000-0002-7439-1492-
crisitem.author.parentorgFaculty of Health Sciences-
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