Please use this identifier to cite or link to this item: https://ktisis.cut.ac.cy/handle/10488/6999
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dc.contributor.authorPapathanassoglou, Elizabethen
dc.contributor.authorChristou, Helenen
dc.contributor.authorConnors, Jean Marieen
dc.contributor.otherΠαπαθανάσογλου, Ελισάβετ-
dc.date.accessioned2013-02-13T13:42:22Zen
dc.date.accessioned2013-05-16T08:36:44Z-
dc.date.accessioned2015-12-02T09:40:42Z-
dc.date.available2013-02-13T13:42:22Zen
dc.date.available2013-05-16T08:36:44Z-
dc.date.available2015-12-02T09:40:42Z-
dc.date.issued2001en
dc.identifier.citationJournal of clinical endocrinology and metabolism, 2001, Volume 86, Issue 2, Pages 935-938en
dc.identifier.issn0021-972Xen
dc.identifier.urihttp://ktisis.cut.ac.cy/handle/10488/6999en
dc.description.abstractThe insulin-like growth factor (IGF) system is the dominant endocrine regulator of fetal growth, whereas insulin has a permissive role. Although a role for leptin in fetal growth has been suggested recently, the mechanism by which leptin may be related to fetal growth is not known; but leptin may interact with the IGF system in utero as it does in the extrauterine life. In the context of a hospital-based case control study, we collected anthropometric and demographic data and measured serum leptin, IGF-I, IGF-II, insulin, cortisol, and IGF binding protein 3 concentrations in 142 cord blood samples from full-term deliveries. Cord leptin, IGF-I, and insulin levels correlated positively with birth weight (r = 0.46, r = 0.41, and r = 0.21, respectively, P < 0.01) by univariate analysis and were significantly higher in large-for-gestational-age (LGA) infants, compared with appropriate-for-gestational-age (AGA) infants. Cord leptin concentrations correlated with insulin levels (r = 0.36, P<0.01) but not with IGF-I levels (r = 0.20). Multiple linear and logistic regression analysis demonstrated an independent positive relationship of both leptin and IGF-I with birth weight and AGA/LGA status. The positive association of leptin levels with birth weight and AGA/LGA status cannot be attributed to IGF-I. This suggests the existence of alternative mechanisms underlying leptin's associations with fetal growth that should be further exploreden
dc.language.isoenen
dc.publisherThe Endocrine Societyen
dc.rightsCopyright © 2001 by The Endocrine Societyen
dc.subjectEndocrinologyen
dc.subjectMetabolismen
dc.subjectInsulinen
dc.subjectLeptinen
dc.subjectFetus--Developmenten
dc.subjectHydrocortisoneen
dc.subjectBirth weighten
dc.titleCord blood leptin and insulin-like growth factor levels are independent predictors of fetal growthen
dc.typeArticleen
dc.affiliationBeth Israel Deaconess Medical Centeren
dc.identifier.doi10.1210/jc.86.2.935en
dc.dept.handle123456789/54en
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1other-
crisitem.author.deptDepartment of Nursing-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.orcid0000-0002-7439-1492-
crisitem.author.parentorgFaculty of Health Sciences-
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