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Title: Probing for missing links in the binary and ternary V(V)-citrate-(H 2O 2) systems: Synthetic efforts and in vitro insulin mimetic activity studies
Authors: Gabriel, Catherine 
Venetis, J. 
Kaliva, Maria 
Raptopoulou, Catherine P. 
Terzis, Aris 
Meier, Beate 
Voyiatzis, George A. 
Potamitis, Constantinos 
Salifoglou, Athanasios 
Drouza, Chryssoula 
Major Field of Science: Natural Sciences
Field Category: Biological Sciences
Keywords: Citric acid;Hydrogen peroxide;Mice;Oxidation;Animals;Biomimetics;Cell lines;Citrates;Crystallography;Hydrogen peroxide;Vanadium picolinate;Cell toxicity;Insulin mimesis;In vitro cell culture tests
Issue Date: Apr-2009
Source: Journal of inorganic biochemistry, 2009, vol. 103, no. 4, pp. 503-516
Volume: 103
Issue: 4
Start page: 503
End page: 516
Journal: Journal of Inorganic Biochemistry 
Abstract: In a pH-specific fashion, V 2O 5 and citric acid in the absence and presence of H 2O 2 reacted and afforded, in the presence of NaOH and (CH 6N 3) 2CO 3, two new dinuclear V(V) binary non-peroxo (CH 6N 3) 6[V 2O 4 (C 6H 4O 7) 2] · 2H 2O (1) and ternary peroxo (CH 6N 3) 4[V 2O 2 (Ο 2) 2(C 6H 5O 7) 2] · 6Η 2Ο (2) species, respectively. Complexes 1 and 2 were further characterized by elemental analysis, UV/Vis, FT-IR, NMR (solution and solid state Cross Polarization-Magic Angle Spinning (CP-MAS)) and Raman spectroscopies, cyclic voltammetry, and X-ray crystallography. Both 1 and 2 are members of the family of dinuclear V(V)-citrate species bearing citrate with a distinct coordination mode and degree of deprotonation, with 2 being the missing link in the family of pH-structural variants of the ternary V(V)-peroxo-citrate system. Given that 1 and 2 possess distinct structural features, relevant binary V(III), V(IV) and V(V), and ternary V(V) species bearing O- and N-containing ligands were tested in in vitro cell cultures to assess their cellular toxicity and insulin mimetic capacity. The results project a clear profile for all species tested, earmarking the importance of vanadium oxidation state and its ligand environment in influencing further binary and ternary interactions of vanadium arising with variable mass cellular targets, ultimately leading to a specific (non)toxic phenotype and glucose uptake ability
ISSN: 0162-0134
DOI: 10.1016/j.jinorgbio.2008.12.018
Rights: © Elsevier
Type: Article
Affiliation : Aristotle University of Thessaloniki 
University of Crete 
NCSR Demokritos 
Cyprus University of Technology 
Foundation of Research and Technology of Greece 
National Hellenic Research Foundation 
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