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Title: Asthma: the role of low high-density-lipoprotein cholesterol in childhood and adolescence
Authors: Yiallouros, Panayiotis K. 
Savva, Savvas C. 
Kolokotroni, Ourania 
Dima, Kleanthi 
Zerva, Aikaterini 
Kouis, Panagiotis 
Bousquet, Jean 
Middleton, Nicos 
Major Field of Science: Medical and Health Sciences
Field Category: Clinical Medicine
Keywords: Asthma;Childhood;Lipid transfer protein;Pediatric allergy
Issue Date: Dec-2014
Source: International Archives of Allergy and Immunology, 2014, vol. 165, no. 2, pp. 91-99
Volume: 165
Issue: 2
Start page: 91
End page: 99
Journal: International Archives of Allergy and Immunology 
Abstract: Background: Several studies have examined the relationship of asthma with serum dyslipidemia and reported positive, negative or no association. Most studies were limited by their cross-sectional design and the wide age range of the participants. In a cohort of children in Cyprus, we explored the association of asthma with serum high-density-lipoprotein cholesterol (HDL-C) at age 16-18 years (follow-up) independently of and in relation to HDL-C at age 11-12 years (baseline). Methods: In a case-control design, we recruited active asthmatics (AA; n = 68), current wheezers only (CWO; n = 123) and non-asthmatic controls (n = 660). Logistic regression models were used to evaluate associations of asthma with follow-up serum HDL-C and the role of baseline HDL-C. Results: At follow-up, mean HDL-C levels in AA and CWO patients were significantly lower than in the controls (47.9 and 49.7 vs. 53.4 mg/dl; p = 0.001 and p = 0.011). We observed significant associations of AA patients with low HDL-C (<15th percentile; OR 2.32, 95% CI 1.16-4.47) that remained significant after further adjustment for baseline HDL-C (OR 2.14, 95% CI 1.06-4.14). Stratification by baseline HDL-C indicated that the association was significant only in those with high baseline HDL-C (OR 2.40, 95% CI 1.03-5.20). Stratification by IgE sensitization showed that the association was pronounced only in subjects who were sensitized (OR 3.41, 95% CI 1.12-9.88). Conclusions: Adolescent asthma is associated with low serum HDL-C independent of previous HDL-C levels in childhood. The association appears pronounced in those with a drop in HDL-C levels between childhood and adolescence and in those who have IgE sensitization.
ISSN: 1423-0097
DOI: 10.1159/000368405
Rights: © Karger
Type: Article
Affiliation : Universitaire Arnaud de Villeneuve 
Attikon University Hospital 
University of Nicosia 
Cyprus University of Technology 
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