Please use this identifier to cite or link to this item:
|Title:||Asthma: the role of low high-density-lipoprotein cholesterol in childhood and adolescence||Authors:||Yiallouros, Panayiotis K.
Savva, Savvas C.
|Keywords:||Asthma;Childhood;Lipid transfer protein;Pediatric allergy||Category:||Clinical Medicine||Field:||Medical and Health Sciences||Issue Date:||Dec-2014||Publisher:||S. Karger AG||Source:||International Archives of Allergy and Immunology, 2014, Volume 165, Issue 2, Pages 91-99||Abstract:||Background: Several studies have examined the relationship of asthma with serum dyslipidemia and reported positive, negative or no association. Most studies were limited by their cross-sectional design and the wide age range of the participants. In a cohort of children in Cyprus, we explored the association of asthma with serum high-density-lipoprotein cholesterol (HDL-C) at age 16-18 years (follow-up) independently of and in relation to HDL-C at age 11-12 years (baseline). Methods: In a case-control design, we recruited active asthmatics (AA; n = 68), current wheezers only (CWO; n = 123) and non-asthmatic controls (n = 660). Logistic regression models were used to evaluate associations of asthma with follow-up serum HDL-C and the role of baseline HDL-C. Results: At follow-up, mean HDL-C levels in AA and CWO patients were significantly lower than in the controls (47.9 and 49.7 vs. 53.4 mg/dl; p = 0.001 and p = 0.011). We observed significant associations of AA patients with low HDL-C (<15th percentile; OR 2.32, 95% CI 1.16-4.47) that remained significant after further adjustment for baseline HDL-C (OR 2.14, 95% CI 1.06-4.14). Stratification by baseline HDL-C indicated that the association was significant only in those with high baseline HDL-C (OR 2.40, 95% CI 1.03-5.20). Stratification by IgE sensitization showed that the association was pronounced only in subjects who were sensitized (OR 3.41, 95% CI 1.12-9.88). Conclusions: Adolescent asthma is associated with low serum HDL-C independent of previous HDL-C levels in childhood. The association appears pronounced in those with a drop in HDL-C levels between childhood and adolescence and in those who have IgE sensitization.||URI:||http://ktisis.cut.ac.cy/handle/10488/4456||ISSN:||1423-0097||DOI:||10.1159/000368405||Rights:||© S. Karger AG, Basel.||Type:||Article|
|Appears in Collections:||Άρθρα/Articles|
Show full item record
checked on Dec 17, 2018
WEB OF SCIENCETM
checked on Nov 28, 2019
Page view(s) 50160
checked on Dec 6, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.