Please use this identifier to cite or link to this item: https://ktisis.cut.ac.cy/handle/10488/4401
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dc.contributor.authorPapatheodorou, Stefania-
dc.contributor.authorRohrmann, Sabine-
dc.contributor.authorLopez, David S.-
dc.contributor.authorBradwin, Gary-
dc.contributor.authorJoshu, Corinne E.-
dc.contributor.authorKanarek, Norma-
dc.contributor.authorNelson, William G.-
dc.contributor.authorRifai, Nader-
dc.contributor.authorPlatz, Elizabeth A.-
dc.contributor.authorTsilidis, Konstantinos K.-
dc.date.accessioned2015-04-20T07:54:04Z
dc.date.accessioned2015-12-08T11:09:34Z-
dc.date.available2015-04-20T07:54:04Z
dc.date.available2015-12-08T11:09:34Z-
dc.date.issued2014-03-
dc.identifier.citationCancer Causes & Control, 2014, vol. 25, no. 3, pp. 353-363en_US
dc.identifier.issn1573-7225-
dc.description.abstractPurpose Sex steroid hormone concentrations and insulin-like growth factor (IGF) proteins have been independently associated with risk of cancer, chronic diseases, and mortality. However, studies that evaluated the inter-relation between the sex hormones and IGF pathways have provided mixed results. We examined the association between endogenous sex hormones and sex hormone-binding globulin (SHBG) with IGF-1 and IGF-binding protein 3 (IGFBP-3) in a population-based sample of US men. Methods Data from 1,135 men aged 20 years or older participating in the third National Health and Nutrition Examination Survey (NHANES III) were analyzed. Weighted linear regression was used to estimate geometric means and 95 % confidence intervals for IGF-1 and IGFBP-3 concentrations by sex steroid hormones and SHBG after adjusting for age, race/ethnicity, body mass index, waist circumference, alcohol consumption, cigarette smoking, physical activity, diabetes, and mutually adjusting for other sex hormones and SHBG. Results No significant association was observed between sex steroid hormones, SHBG, and IGF-1 concentrations. Total estradiol (% difference in Q5 − Q1 geometric means −9.7 %; P-trend 0.05) and SHBG (% difference −7.3 %; P-trend 0.02) were modestly inversely associated with IGFBP-3. Total testosterone was modestly inversely associated with IGFBP-3 (% difference −6.2 %; P-trend 0.01), but this association disappeared after adjustment for total estradiol and SHBG (% difference 2.6 %; P-trend 0.23). Androstanediol glucuronide was not associated with IGFBP-3. Conclusions These findings suggest that there may be inter-relationships between circulating total estradiol, SHBG, and IGFBP-3 concentrations. Future research may consider these inter-relationships when evaluating potential joint effects of the sex hormones and IGF pathways.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.publisherSpringeren
dc.relation.ispartofCancer Causes & Controlen_US
dc.rights© Springer Natureen_US
dc.subjectTestosteroneen_US
dc.subjectEstradiolen_US
dc.subjectSex hormone-binding globulin (SHBG)en_US
dc.subjectInsulin growth factor-1 (IGF-1)en_US
dc.subjectInsulin growth factor-binding protein 3 (IGFBP-3)en_US
dc.titleAssociation between endogenous sex steroid hormones and insulin-like growth factor proteins in US menen_US
dc.typeArticleen_US
dc.collaborationCyprus University of Technologyen_US
dc.collaborationUniversity of Zurichen_US
dc.collaborationUniversity of Texasen_US
dc.collaborationHarvard Medical Schoolen_US
dc.collaborationJohns Hopkins Bloomberg School of Public Healthen_US
dc.collaborationJohns Hopkins Medical Institutionsen_US
dc.collaborationUniversity of Ioanninaen_US
dc.subject.categoryClinical Medicineen_US
dc.journalsSubscriptionen_US
dc.reviewPeer Revieweden
dc.countryCyprusen_US
dc.countrySwitzerlanden_US
dc.countryGreeceen_US
dc.countryUSAen_US
dc.subject.fieldMedical and Health Sciencesen_US
dc.identifier.doi10.1007/s10552-013-0336-4en_US
dc.identifier.pmid24395140-
dc.dept.handle123456789/108en
dc.relation.issue3en_US
dc.relation.volume25en_US
cut.common.academicyear2013-2014en_US
dc.identifier.spage353en_US
dc.identifier.epage363en_US
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.openairetypearticle-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextnone-
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