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|Title:||Association of proinflammatory molecules with apoptotic markers and survival in critically ill multiple organ dysfunction patients||Authors:||Papathanassoglou, Elizabeth
Mantzoros, Christos S.
|Keywords:||MODS;Apoptosis;Fas;Cytokines;Nitric oxide;Cortisol;Interleukin-6;Tumor necrosis factor-α||Category:||Health Sciences||Field:||Medical and Health Sciences||Issue Date:||2003||Publisher:||Sage Publications||Source:||Biological Research for Nursing, 2003, Volume 5, Number 2, Pages 129-141||Link:||http://brn.sagepub.com/content/5/2/129.abstract||Abstract:||Recent evidence supports the involvement of apoptosis in multiple organ dysfunction (MODS). The authors examined the hypothesis that nitric oxide (NO), interleukin (IL)-6, tumor necrosis factor (TNF)-α, and cortisol correlate with Fas and Fas ligand (FasL) expression on peripheral blood mononuclear cells and that Fas and FasL, therefore, mediate their association with MODS severity. Thirty-five critically ill adult MODS patients were followed for up to 14 days and were compared to non-MODS matched controls. Fas, FasL, nitrate, cortisol, and IL-6 were elevated in MODS patients (P < 0.05). Nitrate and cortisol correlated with Fas expression (P < 0.05). All factors studied, except for TNF-α, correlated with MODS severity (P< 0.05); however, by multivariate analyses, Fas and FasL were independently associated with severity and survival (P < 0.05). The inflammatory molecules studied may mediate the association of apoptotic constituents with MODS severity and survival only in part.||URI:||http://ktisis.cut.ac.cy/handle/10488/4144||ISSN:||1552-4175||Rights:||© Sage Publications||Type:||Article|
|Appears in Collections:||Άρθρα/Articles|
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