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Title: Aptamer-based surface plasmon fibre sensor for thrombin detection
Authors: Bennion, Ian 
Allsop, Thomas D P 
Nagel, David Andrew 
Neal, Ron M. 
Davies, Edward M. 
Mou, Chengbo 
Bond, Peter R. 
Rehman, Saeed Ur 
Kalli, Kyriacos 
Webb, David J. 
Calverhouse, P. 
Mascini, Marco 
Keywords: Aptamers;Biosensing;Buffer solutions;Fibre optic sensors;Fibre sensors;Phase masks;Plasmonic;Post-fabrication;Single mode fibres;Spectral sensitivity;Surface plasmons;Surface relief gratings;Thrombin;Thrombin binding;UV-laser irradiation;Fiber optic sensors;Fibers;Health care;Optical data storage;Plasmons;Sensors;Single mode fibers;Spectroscopy;Surface structure
Category: Electrical Engineering - Electronic Engineering - Information Engineering
Field: Engineering and Technology
Issue Date: Apr-2010
Publisher: SPIE
Source: Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 7715, art. no. 77151C, 2010
Conference: Biophotonics: Photonic Solutions for Better Health Care II 
Abstract: A series of surface plasmonic fibre devices were fabricated using multiple coatings deposited on a lapped section of a single mode fibre and post-fabrication UV laser irradiation processing with a phase mask, producing a surface relief grating structure. These devices showed high spectral sensitivity in the aqueous index regime ranging up to 4000 nm/RIU for wavelength and 800 dB/RIU for intensity. The devices were then coated with human thrombin binding aptamer. Several concentrations of thrombin in buffer solution were made, ranging from 1nM to 1mM. All the concentrations were detectable by the devices demonstrating that sub-nM concentrations may be monitored.
ISBN: 978-081948188-7
ISSN: 1605-7422
DOI: 10.1117/12.854334
Rights: ©2010 SPIE
Type: Conference Papers
Appears in Collections:Δημοσιεύσεις σε συνέδρια/Conference papers

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