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|Title:||Aptamer-based surface plasmon fibre sensor for thrombin detection||Authors:||Bennion, Ian
Allsop, Thomas D P
Nagel, David Andrew
Neal, Ron M.
Davies, Edward M.
Bond, Peter R.
Rehman, Saeed Ur
Webb, David J.
|Keywords:||Aptamers;Biosensing;Buffer solutions;Fibre optic sensors;Fibre sensors;Phase masks;Plasmonic;Post-fabrication;Single mode fibres;Spectral sensitivity;Surface plasmons;Surface relief gratings;Thrombin;Thrombin binding;UV-laser irradiation;Fiber optic sensors;Fibers;Health care;Optical data storage;Plasmons;Sensors;Single mode fibers;Spectroscopy;Surface structure||Category:||Electrical Engineering - Electronic Engineering - Information Engineering||Field:||Engineering and Technology||Issue Date:||Apr-2010||Publisher:||SPIE||Source:||Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 7715, art. no. 77151C, 2010||Conference:||Biophotonics: Photonic Solutions for Better Health Care II||Abstract:||A series of surface plasmonic fibre devices were fabricated using multiple coatings deposited on a lapped section of a single mode fibre and post-fabrication UV laser irradiation processing with a phase mask, producing a surface relief grating structure. These devices showed high spectral sensitivity in the aqueous index regime ranging up to 4000 nm/RIU for wavelength and 800 dB/RIU for intensity. The devices were then coated with human thrombin binding aptamer. Several concentrations of thrombin in buffer solution were made, ranging from 1nM to 1mM. All the concentrations were detectable by the devices demonstrating that sub-nM concentrations may be monitored.||ISBN:||978-081948188-7||ISSN:||1605-7422||DOI:||10.1117/12.854334||Rights:||©2010 SPIE||Type:||Conference Papers|
|Appears in Collections:||Δημοσιεύσεις σε συνέδρια/Conference papers|
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