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Title: Focused ultrasound phantom model for blood brain barrier disruption
Authors: Alekou, Tereza 
Giannakou, Marinos 
Damianou, Christakis A. 
Major Field of Science: Medical and Health Sciences
Field Category: Clinical Medicine
Keywords: BBB;FUS;Phantom;Ultrasound
Issue Date: Feb-2021
Source: Ultrasonics, 2021, vol. 110, articl. no. 106244
Volume: 110
Journal: Ultrasonics 
Abstract: In this paper a high intensity focused ultrasound (FUS) phantom model was developed, in order to be used in experiments for Blood Brain Barrier (BBB) disruption. The target was to create a phantom model that represents the disruption of the BBB during ultrasound application. An appropriate experimental setup was created bearing a single element transducer with diameter 50 mm and geometric focus 100 mm operating at 0.5 MHz. It included a set of tubes and a connector with multiple 0.4 mm openings, through which a suitable liquid is being circulated with a pump. The lesions were sealed with a thin homogenous layer of wax, preventing a liquid leakage. The system was tested successfully with FUS and a liquid leakage was achieved after FUS application. This set up is the first phantom model that has the potential to be utilized as a cost-effective solution for performing experiments for BBB disruption, without the need of using animal models.
ISSN: 0041-624X
DOI: 10.1016/j.ultras.2020.106244
Rights: © Elsevier
Attribution-NonCommercial-NoDerivatives 4.0 International
Type: Article
Affiliation : Cyprus University of Technology 
Appears in Collections:Άρθρα/Articles

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