Please use this identifier to cite or link to this item: https://ktisis.cut.ac.cy/handle/10488/22734
Title: Implication of Dietary Iron-Chelating Bioactive Compounds in Molecular Mechanisms of Oxidative Stress-Induced Cell Ageing
Authors: Barbouti, Alexandra 
Lagopati, Nefeli 
Veroutis, Dimitris 
Goulas, Vlasios 
Evangelou, Konstantinos 
Kanavaros, Panagiotis 
Gorgoulis, Vassilis G 
Galaris, Dimitrios 
Major Field of Science: Medical and Health Sciences
Field Category: Health Sciences
Keywords: Mediterranean diet;Ageing mechanisms;Bioactive dietary compounds;Cellular senescence;Free radicals;Iron-chelating agents;Labile iron;Oxidative stress
Issue Date: 21-Mar-2021
Source: Antioxidants, 2021, vol. 10, no. 3, articl. no. 491
Volume: 10
Issue: 3
Journal: Antioxidants 
Abstract: One of the prevailing perceptions regarding the ageing of cells and organisms is the intracellular gradual accumulation of oxidatively damaged macromolecules, leading to the decline of cell and organ function (free radical theory of ageing). This chemically undefined material known as "lipofuscin," "ceroid," or "age pigment" is mainly formed through unregulated and nonspecific oxidative modifications of cellular macromolecules that are induced by highly reactive free radicals. A necessary precondition for reactive free radical generation and lipofuscin formation is the intracellular availability of ferrous iron (Fe2+) ("labile iron"), catalyzing the conversion of weak oxidants such as peroxides, to extremely reactive ones like hydroxyl (HO•) or alcoxyl (RO•) radicals. If the oxidized materials remain unrepaired for extended periods of time, they can be further oxidized to generate ultimate over-oxidized products that are unable to be repaired, degraded, or exocytosed by the relevant cellular systems. Additionally, over-oxidized materials might inactivate cellular protection and repair mechanisms, thus allowing for futile cycles of increasingly rapid lipofuscin accumulation. In this review paper, we present evidence that the modulation of the labile iron pool distribution by nutritional or pharmacological means represents a hitherto unappreciated target for hampering lipofuscin accumulation and cellular ageing.
URI: https://ktisis.cut.ac.cy/handle/10488/22734
ISSN: 2076-3921
DOI: 10.3390/antiox10030491
Rights: This is an open access article distributed under the Creative Commons Attribution License
Attribution-NonCommercial-NoDerivatives 4.0 International
Type: Article
Affiliation : University of Ioannina 
National and Kapodistrian University of Athens 
Cyprus University of Technology 
Biomedical Research Foundation Academy of Athens 
University of Manchester 
Appears in Collections:Άρθρα/Articles

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