Please use this identifier to cite or link to this item: https://ktisis.cut.ac.cy/handle/10488/22379
Title: Bio-Guided Investigation of Sideritis cypria Methanol Extract Driven by in Vitro Antioxidant and Cytotoxic Assays
Authors: Lytra, Krystalia 
Tomou, Ekaterina Michaela 
Chrysargyris, Antonios 
Christofi, Maria Dolores 
Miltiadous, Panagiota 
Tzortzakis, Nikos G. 
Skaltsa, Helen 
Major Field of Science: Agricultural Sciences
Field Category: Biological Sciences
Keywords: Cultivated Sideritis cypria;Bio-guided;Antioxidant activity;Cytotoxicity;Antimicrobial activity
Issue Date: Mar-2021
Source: Chemistry & Biodiversity, 2021, vol. 18, no. 3, articl. no. e2000966
Volume: 18
Issue: 3
Journal: Chemistry & Biodiversity 
Abstract: Sideritis cypria Post is an endemic and endangered species of Northern Cyprus. The overall aim of the present study was to evaluate the total phenolic content, the antioxidant, the cytotoxic and the antimicrobial activity of the methanol extract obtained from the aerial parts of cultivated S. cypria. A bio-guided approach led to the isolation of 27 chemical compounds by using various analytical techniques. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopy. The crude extract exerted strong antioxidant activity (DPPH and FRAP assays) which was attributed to its high total phenolic content. Furthermore, groups rich in phenolic content showed highest antioxidant property, whereas groups with phytosterols, diterpenoids and apigenin derivatives exerted cytotoxic effects in MDA-MB231 cancer cell line by the MTT method. Moreover, the cytotoxic activity of four isolated apigenin derivatives was evaluated in the same cancer cells. The antimicrobial activity of the extract and groups were measured, demonstrating lack of activity. To the best of our knowledge, this survey is the first report on the biological activities of the methanol extract of S. cypria.
URI: https://ktisis.cut.ac.cy/handle/10488/22379
ISSN: 1612-1880
DOI: 10.1002/cbdv.202000966
Rights: © Wiley
Type: Article
Affiliation : National and Kapodistrian University of Athens 
Cyprus University of Technology 
Appears in Collections:Άρθρα/Articles

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