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|Title:||Σύνθεση και Χαρακτηρισμός Βιολογικά Ενεργών Οξειδοαναγωγικών μορίων Βαναδίου με Πολυφαινικούς υποκαταστάτες||Authors:||Vlasiou, Manolis||Keywords:||ενεργοποίηση οξυγόνου;Βανάδιο;τοκοφερυλικές ρίζες;19F NMR φασματοσκοπία;EPR φασματοσκοπία;πολυφαινόλες;ελαιόλαδα||Advisor:||Keramidas, Anastasios D.
|Issue Date:||Mar-2017||Department:||Department of Chemistry||Abstract:||In this work, we introduce new transition metal complexes with phenolic ligands which are models for the study of metabolic pathways in food matrixes and biological systems. In addition, there was a study upon the mechanism of radicals that created with the interaction of the phenols with metal ions. That possibility was in great interest because of the use of those kinds of systems as anticancer drugs. Finally, we developed an analytical method in order to be able to evaluate these phenol molecules in biological systems. In particular, hydroquinones and tocopherols were fluoro-labelled and vanadium labelled to be easily observed and evaluated with 19F and 51V NMR, EPR and UV-Vis spectroscopy. The quantification of the molecules using the 19F NMR took place in olive oil environment which is very like the cell membrane environment. The antioxidant action of the metal-organic molecules with the metal ions, in addition with the radical induced mechanisms were evaluated with spectroscopy, crystallography and electrochemically. Antioxidants are components of foods and there are biomolecules that are necessary for the ordinary function of human body. They used as conservatives in food matrixes against oxidation. Hydroquinones are model molecules for antioxidants and tocopherols containing a saturated phytyl chain and a different placement of methyl groups on the chromanol ring. Tocotrienol isoforms have an unsaturated side chain. Vitamin E is a generic term that represents a family of compounds composed of various tocopherol and tocotrienol isoforms. Tocopherols display potent anti-angiogenic and antiproliferative activities. Redox silent tocopherol analogues also display potent anticancer activity. Polyphenolic compounds in biological systems could easily interact with metal ions producing free radical species causing several diseases in human body. The true is that controlled production of free radicals could induce apoptosis of cancer cells. Especially vitamin E and its analogues are very active in mitochondria of cells and they are potential drugs acting against cancer cells. It is also well known that tocopherol analogues are targeting only cancer cells because they are very high redox active. Even though the above reactions are very useful there are are some drawbacks in their study. There is a lack of well-known metal -organic molecules with notable mechanism of action. In this work, we are introducing new analytical methods for the determination of those models in order to be able to monitor their metabolic pathways in biological systems and we have studied the redox mechanisms behind this action and their interaction with vanadium metal ions for possible use as anticancer drugs.||URI:||https://ktisis.cut.ac.cy/handle/10488/22271||Rights:||All rights reserved||Type:||PhD Thesis||Affiliation:||University of Cyprus|
|Appears in Collections:||Διδακτορικές Διατριβές/ PhD Theses|
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