Please use this identifier to cite or link to this item: https://ktisis.cut.ac.cy/handle/10488/19187
DC FieldValueLanguage
dc.contributor.authorHadjiadamou, Ioanna-
dc.contributor.authorVlasiou, Manolis-
dc.contributor.authorSpanou, Smaragda-
dc.contributor.authorSimos, Yannis-
dc.contributor.authorPapanastasiou, George-
dc.contributor.authorKontargiris, Evangelos-
dc.contributor.authorDhima, Irida-
dc.contributor.authorRagos, Vasilios-
dc.contributor.authorKarkabounas, Spyridon-
dc.contributor.authorDrouza, Chryssoula-
dc.contributor.authorKeramidas, Anastasios D.-
dc.date.accessioned2020-10-19T09:01:10Z-
dc.date.available2020-10-19T09:01:10Z-
dc.date.issued2020-07-01-
dc.identifier.citationJournal of Inorganic Biochemistry, 2020, vol. 208, article number 111074en_US
dc.identifier.issn01620134-
dc.identifier.urihttps://ktisis.cut.ac.cy/handle/10488/19187-
dc.description.abstractNovel vitamin E chelate derivatives and their VIV/V complexes have been synthesized and characterized, and their anticancer properties have been evaluated. The new complexes have been designed to exhibit enhanced cytotoxicity by combining high lipophilicity with the properties of vanadium to induce the formation of reactive oxygen species (ROS). In particular, the β-tocopherol derivatives with iminodiethanol (β-tocDEA) and dipicolylamine (β-tocDPA) as well their VV and VIV complexes, [VVO(β-tocDEA] and [VIVO(β-tocDPA] have been synthesized and characterized by Nuclear Magnetic Resonance (NMR), Ultra Violet-Visible (UV–Vis) and Electron Paramagnetic Resonance (EPR) spectroscopies. Although the β-tocopherol compounds exhibit antioxidant activity their complexes induce formation of radicals. In addition, two vanadium amphiphilic complexes of 2,2′-((2-hydroxyoctadecyl)azanediyl)bis(ethan-1-ol) (C18DEA) and 1-(bis(pyridin-2-ylmethyl)amino)octadecan-2-ol (C18DPA) known to activate O2 and produce ROS were synthesized and characterized (C. Drouza, A. Dieronitou, I. Hadjiadamou, M. Stylianou, J. Agric. Food. Chem., vol. 65, 2017, pp. 4942–4951). The four amphiphilic vanadium complexes exhibit enhanced hydrolytic stability. All compounds found to be cytotoxic for cancer cells exhibiting activity similar or higher to cis-platin.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Inorganic Biochemistryen_US
dc.rights© Elsevieren_US
dc.subjectCytotoxicen_US
dc.subjectRadicalsen_US
dc.subjectTocopherolen_US
dc.subjectVanadiumen_US
dc.subjectVitamin Een_US
dc.titleSynthesis of vitamin E and aliphatic lipid vanadium(IV) and (V) complexes, and their cytotoxic propertiesen_US
dc.typeArticleen_US
dc.collaborationUniversity of Cyprusen_US
dc.collaborationCyprus University of Technologyen_US
dc.collaborationUniversity of Ioanninaen_US
dc.subject.categoryAgricultural Biotechnologyen_US
dc.journalsSubscriptionen_US
dc.countryCyprusen_US
dc.countryGreeceen_US
dc.subject.fieldAgricultural Sciencesen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.1016/j.jinorgbio.2020.111074en_US
dc.identifier.pmid32497827en
dc.identifier.scopus2-s2.0-85085625171en
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85085625171en
dc.contributor.orcid#NODATA#en
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dc.relation.volume208en_US
cut.common.academicyear2020-2021en_US
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.openairetypearticle-
crisitem.journal.journalissn0162-0134-
crisitem.journal.publisherElsevier-
crisitem.author.deptDepartment of Agricultural Sciences, Biotechnology and Food Science-
crisitem.author.deptDepartment of Agricultural Sciences, Biotechnology and Food Science-
crisitem.author.facultyFaculty of Geotechnical Sciences and Environmental Management-
crisitem.author.facultyFaculty of Geotechnical Sciences and Environmental Management-
crisitem.author.orcid0000-0002-2630-4323-
crisitem.author.parentorgFaculty of Geotechnical Sciences and Environmental Management-
crisitem.author.parentorgFaculty of Geotechnical Sciences and Environmental Management-
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