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Title: Synthesis of vitamin E and aliphatic lipid vanadium(IV) and (V) complexes, and their cytotoxic properties
Authors: Hadjiadamou, Ioanna 
Vlasiou, Manolis 
Spanou, Smaragda 
Simos, Yannis 
Papanastasiou, George 
Kontargiris, Evangelos 
Dhima, Irida 
Ragos, Vasilios 
Karkabounas, Spyridon 
Drouza, Chryssoula 
Keramidas, Anastasios D. 
Major Field of Science: Agricultural Sciences
Field Category: Agricultural Biotechnology
Keywords: Cytotoxic;Radicals;Tocopherol;Vanadium;Vitamin E
Issue Date: 1-Jul-2020
Source: Journal of Inorganic Biochemistry, 2020, vol. 208, article number 111074
Volume: 208
Journal: Journal of Inorganic Biochemistry 
Abstract: Novel vitamin E chelate derivatives and their VIV/V complexes have been synthesized and characterized, and their anticancer properties have been evaluated. The new complexes have been designed to exhibit enhanced cytotoxicity by combining high lipophilicity with the properties of vanadium to induce the formation of reactive oxygen species (ROS). In particular, the β-tocopherol derivatives with iminodiethanol (β-tocDEA) and dipicolylamine (β-tocDPA) as well their VV and VIV complexes, [VVO(β-tocDEA] and [VIVO(β-tocDPA] have been synthesized and characterized by Nuclear Magnetic Resonance (NMR), Ultra Violet-Visible (UV–Vis) and Electron Paramagnetic Resonance (EPR) spectroscopies. Although the β-tocopherol compounds exhibit antioxidant activity their complexes induce formation of radicals. In addition, two vanadium amphiphilic complexes of 2,2′-((2-hydroxyoctadecyl)azanediyl)bis(ethan-1-ol) (C18DEA) and 1-(bis(pyridin-2-ylmethyl)amino)octadecan-2-ol (C18DPA) known to activate O2 and produce ROS were synthesized and characterized (C. Drouza, A. Dieronitou, I. Hadjiadamou, M. Stylianou, J. Agric. Food. Chem., vol. 65, 2017, pp. 4942–4951). The four amphiphilic vanadium complexes exhibit enhanced hydrolytic stability. All compounds found to be cytotoxic for cancer cells exhibiting activity similar or higher to cis-platin.
ISSN: 01620134
DOI: 10.1016/j.jinorgbio.2020.111074
Rights: © Elsevier
Type: Article
Affiliation : University of Cyprus 
Cyprus University of Technology 
University of Ioannina 
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