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Title: Cancer incidence and mortality in firefighters: A state-of-the-art review and meta-analysis
Authors: Soteriades, Elpidoforos Soterakis 
Kim, Jaeyoung 
Christophi, Costas A. 
Kales, Stefanos N. 
Major Field of Science: Medical and Health Sciences
Field Category: Clinical Medicine
Keywords: Cancer incidence;Mortality;Firefighters;Systematic review;Meta-analysis
Issue Date: Nov-2019
Source: Asian Pacific Journal of Cancer Prevention, 2019, vol. 20, no. 11, pp. 3221-3231
Volume: 20
Issue: 11
Start page: 3221
End page: 3231
Journal: Asian Pacific Journal of Cancer Prevention 
Abstract: Objective: A systematic literature review and meta-analysis was conducted on the association between firefighting and cancer. Methods: A comprehensive literature search of databases including Medline, EMBASE, Biosis, NIOSHTIC2, Web of Science, Cancerlit, and HealthStar, for the period between 1966 to January 2007, was conducted. We also retrieved additional studies by manual searching. Results: A total of 49 studies were included in the meta-analysis. We found statistically significant associations between firefighting and cancers of bladder, brain and CNS, and colorectal cancers, consistent with several previous risk estimates. We also found statistically significant associations of firefighting with non-Hodgkin’s lymphoma, skin melanoma, prostate, and testicular cancer. For kidney, Hodgkin’s lymphoma, leukemia, lymphosarcoma and reticulosarcoma, multiple myeloma, and pancreatic cancer, we found some statistically significant but less consistent results. For all other cancers evaluated (esophageal, laryngeal, oral and pharyngeal, liver and gallbladder, lung, lymphatic and hematopoietic, non-melanoma skin cancer, stomach, and urinary cancer) we did not find any statistically significant associations. Conclusions: Although our meta-analysis showed statistically significant increased risks of either cancer incidence or mortality of certain cancers in association with firefighting, a number of important limitations of the underlying studies exist, which, precluded our ability to arrive at definitive conclusions regarding causation.
ISSN: 1513-7368
DOI: 10.31557/APJCP.2019.20.11.3221
Rights: This work is licensed under a Creative Commons AttributionNon Commercial 4.0 International License.
Attribution-NonCommercial-NoDerivatives 4.0 International
Type: Article
Affiliation : United Arab Emirates University-College of Medicine and Health Sciences 
Harvard T.H. Chan School of Public Health 
Keimyung University 
Cyprus University of Technology 
George Washington University 
Cambridge Health Alliance 
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