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Title: Neuropsychological and syntactic deficits in HIV seropositive males
Authors: Kambanaros, Maria 
Messinis, Lambros 
Psichogiou, Mina 
Leonidou, Lydia 
Gogos, Charalambos A. 
Nasios, Grigorios 
Papathanasopoulos, Panagiotis 
Major Field of Science: Medical and Health Sciences
Field Category: Clinical Medicine
Keywords: HIV;Neurocognitive impairment;Speech-language pathologists;Sentence repetition;Complex syntax;Cognition;Linguistic screening
Issue Date: 2019
Source: Open Neurology Journal, vol. 13, no. 1, pp. 107-118
Volume: 13
Issue: 1
Start page: 107
End page: 118
Journal: Open Neurology Journal 
Abstract: Objective: Given the underlying frontal-basal ganglia circuit neuropathogenesis of HIV-infected individuals, it is surprising that little is reported about potential language deficits as part of their higher cognitive dysfunctional profile. This study aims to elucidate whether HIV-positive individuals have linguistic impairments that may originate from or be intensified by deficits in cognitive functions. The research questions address (i) quantitative differences in sentence repetition abilities involving complex syntactic phenomena between adults with HIV and non-HIV healthy controls (ii) correlations of sentence repetition scores with neurocognitive measures and (iii) correlation of sentence repetition performance with duration and severity of HIV. Methods: A battery of neuropsychological tests were administered to 40 HIV-seropositive males and 40 demographically matched healthy controls to assess verbal learning/episodic memory, psychomotor speed, executive functions and visuospatial abilities. Language abilities were evaluated using a repetition task that screened specific complex syntactic operations at the sentence-level. Results: A significant difference was noted between the two groups regarding correct repetition of the sentence repetition task with the control group outperforming the HIV-seropositive group. For the HIV group, significant correlations were found for correct sentence repetition with years of education, duration of illness, Mini-Mental State Examination, semantic and phonemic fluency, symbol digit modality test scores, and the Trail Making Test (parts A and B). Conclusion: Speech-language pathologists and neuropsychologists should screen for language deficits associated with the different clinical syndromes in HIV patients as part of their routine clinical care.
ISSN: 1874-205X
DOI: 10.2174/1874205X01913010107
Rights: © 2019 Kambanaros et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Attribution-NonCommercial-NoDerivatives 4.0 International
Type: Article
Affiliation : Cyprus University of Technology 
University of Patras Medical School 
National and Kapodistrian University of Athens 
University of Ioannina 
Appears in Collections:Άρθρα/Articles

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