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Title: Missing Value Estimation for DNA Microarrays with Mutliresolution Schemes
Authors: Vogiatzis, Dimitrios 
Tsapatsoulis, Nicolas 
Keywords: Neural networks (Computer science)--Congresses;Artificial intelligenceCongresses
Issue Date: 2006
Publisher: Springer Berlin / Heidelberg
Source: Artificial Neural Networks – ICANN 2006, pp.141-150
Series/Report no.: Lecture Notes in Computer Science;
Abstract: The expression pattern of a gene across time can be considered as a signal; a microarray experiment is collection of thousands of such signals where due to instrument failure, human errors and technology limitations, values at some time instances are usually missing. Furthermore, in some microarray experiments the gene signals are not sampled at regular time intervals, which renders the direct use of well established frequency-temporal signal analysis approaches such as the wavelet transform problematic. In this work we evaluate a novel multiresolution method, known as the lifting transform to estimate missing values in time series microarray data. Though the lifting transform has been developed to deal with irregularly spaced data its usefulness for the estimation of missing values in microarray data has not been examined in detail yet. In this framework we evaluate the lifting transform against the wavelet transform, a moving average method and a zero imputation on 5 data sets from the cell cycle and the sporulation of the saccharomyces cerevisiae.
Description: 16th International Conference, Athens, Greece, September 10-14, 2006. Proceedings, Part II
ISBN: 9783540388715
ISSN: 10.1007/11840930
DOI: 10.1007/11840930
Rights: © Springer
Type: Book Chapter
Appears in Collections:Κεφάλαια βιβλίων/Book chapters

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