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Title: Quantitative analysis of aqueous phase composition of model dentin adhesives experiencing phase separation
Authors: Spencer, Paulette 
Park, Jonggu 
Misra, Anil S.
Ye, Qiang 
Laurence, Jennifer S. 
Pamatmat, Francis 
Parthasarathy, Ranganathan 
Marangos, Orestes 
Keywords: dentin adhesive;hydrophilic;hydrophobic;phase separation;water
Category: Civil Engineering
Field: Engineering and Technology
Issue Date: 1-May-2012
Source: Journal of Biomedical Materials Research - Part B Applied Biomaterials, Volume 100 B, Issue 4, May 2012, Pages 1086-1092
Abstract: There have been reports of the sensitivity of our current dentin adhesives to excess moisture, for example, water-blisters in adhesives placed on over-wet surfaces, and phase separation with concomitant limited infiltration of the critical dimethacrylate component into the demineralized dentin matrix. To determine quantitatively the hydrophobic/hydrophilic components in the aqueous phase when exposed to over-wet environments, model adhesives were mixed with 16, 33, and 50 wt % water to yield well-separated phases. Based upon high-performance liquid chromatography coupled with photodiode array detection, it was found that the amounts of hydrophobic BisGMA and hydrophobic initiators are less than 0.1 wt % in the aqueous phase. The amount of these compounds decreased with an increase in the initial water content. The major components of the aqueous phase were hydroxyethyl methacrylate (HEMA) and water, and the HEMA content ranged from 18.3 to 14.7 wt %. Different BisGMA homologues and the relative content of these homologues in the aqueous phase have been identified; however, the amount of crosslinkable BisGMA was minimal and, thus, could not help in the formation of a crosslinked polymer network in the aqueous phase. Without the protection afforded by a strong crosslinked network, the poorly photoreactive compounds of this aqueous phase could be leached easily. These results suggest that adhesive formulations should be designed to include hydrophilic multimethacrylate monomers and water compatible initiators. © 2012 WILEY PERIODICALS, INC.
ISSN: 15524973
DOI: 10.1002/jbm.b.32675
Type: Article
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