Please use this identifier to cite or link to this item: https://ktisis.cut.ac.cy/handle/10488/13694
DC FieldValueLanguage
dc.contributor.authorCharalambous, Andreas-
dc.contributor.authorGiannakopoulou, Margarita-
dc.contributor.authorBozas, Evaggelos-
dc.contributor.authorPaikousis, Lefkios-
dc.date.accessioned2019-05-19T21:16:55Z-
dc.date.available2019-05-19T21:16:55Z-
dc.date.issued2019-01-01-
dc.identifier.citationBMJ Open, 2019, Volume 9, Issue 1, Article number e026809en_US
dc.identifier.issn2044-6055-
dc.identifier.urihttp://ktisis.cut.ac.cy/handle/10488/13694-
dc.description.abstractObjective Cancer treatment is a particularly stressful period for the patient. The reasons vary and include fear of treatment outcome as well as treatment induced side effects. The patient frequently experiences simultaneously various side effects resulting in a diminishing of the patient's health-related quality of life (HRQoL). The study provides evidence on the co-occurrence and inter-relations between pain, anxiety, depression and fatigue in patients with breast and prostate cancer. Design This paper presents a secondary analysis of the data from a randomised control trial designed to test the effectiveness of guided imagery and progressive muscle relaxation on pain, fatigue, anxiety and depression. Non-parametric bootstrapping analyses were used to test the mediational model of anxiety, fatigue and depression as parallel mediators of the relationship between pain and HRQoL. Setting The study was undertaken at the home setting. Participants In total 208 patients were included in the study (assigned equally in two groups), referred at the outpatient clinics of the three participating cancer care centres. Results The three mediators fully mediate the relationship between pain and HRQoL indirect effect (IE overall =-0.3839, 95% CI: Lower limit (LL)=-0.5073 to upper limit (UL)=-0.2825) indicating that patients with increased pain are likely to have higher levels of anxiety, fatigue and depression. Gender significantly moderated the mediational effect of Fatigue Index of Moderated Mediation (IMM=-0.2867 SE=0.1526, LL=-0.6127, UL=-0.0226) but did not moderate mediational effect of anxiety (IMM=-0.0709, SE=0.1414, LL=-0.3459, UL=+0.2089). The results show that the three mediators in a serial causal order fully mediate the relationship between pain and HRQoL (IE overall =-0.384, 95% CI: LL=-0.51 to UL=-0.284) and the ratio of the overall indirect effect to the total effect is 0.8315 (95% CI: LL=0.5683 to UL=1.1718). Conclusion This work provides evidence that targeting fatigue, anxiety and depression may have a meaningful effect on pain as a related symptom and potentially have a positive impact on HRQoL of patients with breast and prostate canceren_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.relation.ispartofBMJ Openen_US
dc.rights© Author(s)en_US
dc.subjectBreast canceren_US
dc.subjectMediation analysisen_US
dc.subjectProstate canceren_US
dc.subjectSymptom clusteren_US
dc.titleParallel and serial mediation analysis between pain, anxiety, depression, fatigue and nausea, vomiting and retching within a randomised controlled trial in patients with breast and prostate canceren_US
dc.typeArticleen_US
dc.collaborationCyprus University of Technologyen_US
dc.collaborationUniversity of Athensen_US
dc.collaborationStatisticsen_US
dc.collaborationUniversity of Turkuen_US
dc.subject.categoryClinical Medicineen_US
dc.journalsOpen Accessen_US
dc.countryCyprusen_US
dc.countryGreeceen_US
dc.countryFinlanden_US
dc.subject.fieldMedical and Health Sciencesen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.1136/bmjopen-2018-026809en_US
cut.common.academicyear2018-2019en_US
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.openairetypearticle-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
crisitem.author.deptDepartment of Nursing-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.orcid0000-0003-4050-031X-
crisitem.author.parentorgFaculty of Health Sciences-
crisitem.journal.journalissn2044-6055-
Appears in Collections:Άρθρα/Articles
Files in This Item:
File Description SizeFormat
e026809.full.pdfFulltext719.15 kBAdobe PDFView/Open
Show simple item record

WEB OF SCIENCETM
Citations

1
checked on Dec 1, 2019

Page view(s)

19
Last Week
0
Last month
1
checked on Dec 7, 2019

Download(s)

10
checked on Dec 7, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.