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Title: Study on the packed volume-to-void ratio of idealized human red blood cells using a finite-discrete element method
Authors: Xu, Dong 
Ji, Chunning 
Munjiza, Antonio A. 
Kaliviotis, Efstathios 
Avital, Eldad Jitzchak 
Willams, J. 
Major Field of Science: Medical and Health Sciences
Field Category: Basic Medicine
Keywords: Discrete element method;Packed volume;Q291;Red blood cell (RBC);Void ratio
Issue Date: 1-May-2019
Source: Applied Mathematics and Mechanics, 2019, vol.40, no. 5, pp. 737-750
Volume: 40
Issue: 5
Start page: 737
End page: 750
Journal: Applied Mathematics and Mechanics 
Abstract: Numerical simulations are performed to examine the packing behavior of human red blood cells (RBCs). A combined finite-discrete element method (FDEM) is utilized, in which the RBCs are modeled as no-friction and no-adhesion solid bodies. The volume-to-void ratio of a large number of randomly packed RBCs is clarified, and the effects of the RBC shape, the mesh size, the cell number, and the container size are investigated. The results show that the packed human RBCs with normal shape have a void ratio of 28.45%, which is slightly higher than that of the flat or thick cells used in this study. Such information is beneficial to the further understanding on the geometric features of human RBCs and the research on RBC simulations.
ISSN: 1573-2754
DOI: 10.1007/s10483-019-2473-6
Rights: © Shanghai University and Springer
Type: Article
Affiliation : Tianjin University 
Queen Mary University of London 
Cyprus University of Technology 
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