Please use this identifier to cite or link to this item: https://ktisis.cut.ac.cy/handle/10488/13616
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dc.contributor.authorGiannakou, Konstantinos-
dc.contributor.authorEvangelou, Evangelos-
dc.contributor.authorYiallouros, Panayiotis K.-
dc.contributor.authorChristophi, Costas A.-
dc.contributor.authorMiddleton, Nicos-
dc.contributor.authorPapatheodorou, Evgenia-
dc.contributor.authorPapatheodorou, Stefania-
dc.date.accessioned2019-05-13T19:57:33Z-
dc.date.available2019-05-13T19:57:33Z-
dc.date.issued2019-04-
dc.identifier.citationPLoS ONE, 2019, vol. 14, no. 4en_US
dc.identifier.issn1932-6203-
dc.description.abstractBackground/Objective Gestational diabetes mellitus (GDM) is a common pregnancy complication, with complex disease mechanisms, and several risk factors may contribute to its onset. We performed an umbrella review to summarize the evidence from meta-analyses of observational studies on risk factors associated with GDM, evaluate whether there are indications of biases in this literature and identify which of the previously reported associations are supported by convincing evidence. Methods We searched PubMed and ISI Web of Science from inception to December 2018 to identify meta-analyses examining associations between putative risk factors for GDM. For each meta-analysis we estimated the summary effect size, the 95% confidence interval, the 95% prediction interval, the between-study heterogeneity, evidence of small-study effects, and evidence of excess-significance bias. Results Thirty eligible meta-analyses were identified, providing data on 61 associations. Fifty (82%) associations had nominally statistically significant findings (P<0.05), while only 15 (25%) were significant at P<10 -6 under the random-effects model. Only four risk factors presented convincing evidence:, low vs. normal BMI (cohort studies), BMI ∼30-35 kg/m2 vs. normal BMI, BMI >35 kg/m2 vs. normal BMI, and hypothyroidism. Conclusions The compilation of results from synthesis of observational studies suggests that increased BMI and hypothyroidism show the strongest consistent evidence for an association with GDM. Diet and lifestyle modifications in pregnancy should be tested in large randomized trials. Our findings suggest that women with known thyroid disease may be offered screening for GDM earlier in pregnancy.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.relation.ispartofPLoS ONEen_US
dc.rights© Giannakou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.subjectEvidence based medicineen_US
dc.subjectPregnancy diabetes mellitusen_US
dc.subjectPregnancy diabetes mellitusen_US
dc.subjectHypothyroidismen_US
dc.titleRisk factors for gestational diabetes: An umbrella review of meta-analyses of observational studiesen_US
dc.typeArticleen_US
dc.collaborationCyprus University of Technologyen_US
dc.collaborationUniversity of Ioanninaen_US
dc.collaborationImperial College Londonen_US
dc.collaborationUniversity of Cyprusen_US
dc.collaborationKentro Iatrikis Ioanninonen_US
dc.collaborationHarvard T.H. Chan School of Public Healthen_US
dc.subject.categoryClinical Medicineen_US
dc.journalsOpen Accessen_US
dc.countryCyprusen_US
dc.countryGreeceen_US
dc.countryUnited Kingdomen_US
dc.countryUnited Statesen_US
dc.subject.fieldMedical and Health Sciencesen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.1371/journal.pone.0215372en_US
dc.relation.issue4en_US
dc.relation.volume14en_US
cut.common.academicyear2018-2019en_US
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.openairetypearticle-
crisitem.journal.journalissn1932-6203-
crisitem.journal.publisherPloS-
crisitem.author.deptCyprus International Institute for Environmental and Public Health-
crisitem.author.deptCyprus International Institute for Environmental and Public Health-
crisitem.author.deptDepartment of Nursing-
crisitem.author.deptCyprus International Institute for Environmental and Public Health-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.orcid0000-0002-8339-9285-
crisitem.author.orcid0000-0003-0503-1538-
crisitem.author.orcid0000-0001-6358-8591-
crisitem.author.orcid0000-0002-9451-9094-
crisitem.author.parentorgFaculty of Health Sciences-
crisitem.author.parentorgFaculty of Health Sciences-
crisitem.author.parentorgFaculty of Health Sciences-
crisitem.author.parentorgFaculty of Health Sciences-
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