Please use this identifier to cite or link to this item: https://ktisis.cut.ac.cy/handle/10488/13582
DC FieldValueLanguage
dc.contributor.authorGoulas, Vlasios-
dc.contributor.authorNicolaou, Demetra-
dc.contributor.authorBotsaris, George-
dc.contributor.authorBarbouti, Alexandra-
dc.date.accessioned2019-05-01T09:21:36Z-
dc.date.available2019-05-01T09:21:36Z-
dc.date.issued2018-09-02-
dc.identifier.citationBiomedicines, 2018, vol. 6, no. 3en_US
dc.identifier.issn2227-9059-
dc.description.abstractNumerous studies provide robust evidence for a protective effect of red wine against many diseases. This bioactivity has been mainly associated with phenolic fractions of wines. However, the health effects of melanoidins in red sweet wines has been ignored. The goal of the present work was to unravel the antioxidant, antimicrobial, and angiotensin-I-converting enzyme (ACE) inhibitory properties of straw sweet wine melanoidins. Results demonstrated that melanoidins have a potential antioxidant activity, determined by 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and Ferric reducing antioxidant power (FRAP) assays. The antimicrobial activity of melanoidins was also tested against Listeria monocytogenes, Salmonella Enteritidis, and Escherichia coli. Minimum inhibitory concentration (MIC) of isolated melanoidins against three bacterial strains ranged from 5 mg mL-1 to 10 mg mL-1. Finally, the ACE inhibitory effect of isolated melanoidins was evaluated, as it is linked with antihypertensive activity. Results showed that they have ACE-inhibitory activity ranging from 58.2 ± 5.4% to 75.3 ± 6.4% at a concentration level of 2 mg mL-1. Furthermore, the chemical properties of isolated melanoidins were determined. Results demonstrated that the skeleton of straw wine melanoidins is mainly composed of carbohydrates, and bear significant numbers of phenolic compounds that may play critical roles in their functional properties. Overall, this study describing the chemical composition and functional properties of melanoidin fractions isolated from a straw wine highlights that they can be exploited as functional agents for multiple purposes. Finally, melanoidins are an unexplored source of bioactive molecules in straw wines except from polyphenols that contribute to the health effects.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofBiomedicinesen_US
dc.rights© by the authors.en_US
dc.subjectCommandaria wineen_US
dc.subjectEscherichia colien_US
dc.subjectListeriaen_US
dc.subjectSalmonellaen_US
dc.subjectAngiotensin I converting activityen_US
dc.subjectRadical scavenging activityen_US
dc.titleStraw Wine Melanoidins as Potential Multifunctional Agents: Insight into Antioxidant, Antibacterial, and Angiotensin-I-Converting Enzyme Inhibition Effectsen_US
dc.typeArticleen_US
dc.collaborationCyprus University of Technologyen_US
dc.collaborationUniversity of Ioanninaen_US
dc.subject.categoryAgriculture Forestry and Fisheriesen_US
dc.journalsOpen Accessen_US
dc.countryCyprusen_US
dc.countryGreeceen_US
dc.subject.fieldAgricultural Sciencesen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.3390/biomedicines6030083en_US
dc.identifier.pmid30072595-
dc.identifier.scopus2-s2.0-85063945087-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85063945087-
dc.relation.issue3en_US
dc.relation.volume6en_US
cut.common.academicyear2017-2018en_US
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.openairetypearticle-
crisitem.journal.journalissn2227-9059-
crisitem.journal.publisherMDPI-
crisitem.author.deptDepartment of Agricultural Sciences, Biotechnology and Food Science-
crisitem.author.deptDepartment of Agricultural Sciences, Biotechnology and Food Science-
crisitem.author.facultyFaculty of Geotechnical Sciences and Environmental Management-
crisitem.author.facultyFaculty of Geotechnical Sciences and Environmental Management-
crisitem.author.orcid0000-0001-7527-1559-
crisitem.author.orcid0000-0003-3197-6535-
crisitem.author.parentorgFaculty of Geotechnical Sciences and Environmental Management-
crisitem.author.parentorgFaculty of Geotechnical Sciences and Environmental Management-
Appears in Collections:Άρθρα/Articles
Files in This Item:
File Description SizeFormat
biomedicines-06-00083.pdfFulltext5.08 MBAdobe PDFView/Open
CORE Recommender
Show simple item record

Google ScholarTM

Check

Altmetric


Items in KTISIS are protected by copyright, with all rights reserved, unless otherwise indicated.