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Title: Kidney function is associated with short-term, mid-term and long-term clinical outcome after coronary angiography and intervention
Authors: Panayiotou, Andrie G. 
Spaak, Jonas 
Kalani, Majid 
Major Field of Science: Medical and Health Sciences
Field Category: Clinical Medicine
Keywords: EGFR;Mortality;Myocardial infarction;Revascularisation
Issue Date: 4-Jul-2018
Source: Acta Cardiologica, 2018, vol. 73, no. 4, pp. 362-369
Volume: 73
Issue: 4
Start page: 362
End page: 369
Journal: Acta Cardiologica 
Abstract: Background: Patients with kidney dysfunction are at risk of developing ischaemic heart disease. We investigated the association between eGFR and early-, mid- and long-term clinical outcome in patients undergoing coronary angiography and intervention. Methods: Retrospective study on 4968 patients with complete data on eGFR, 65% male and aged 32–80 years, admitted to Danderyd University Hospital, Stockholm, Sweden for coronary angiography and intervention from 2006 to 2008. Data were censored at 0–30 days, 31–365 days and 366–1825 days of follow-up. Results: Baseline eGFR was strongly associated with all-cause mortality at all three time periods studied with each 10 ml/min per 1.73 m2 increase in eGFR being associated with a ∼30% (p < .001), 25% (p = .002) and 20% (p < .001) decrease in all-cause mortality at 30, 365 and 1825 days respectively. Each 10 ml/min per 1.73 m2 increase in eGFR was associated with a ∼21% (p < .001) decrease in re-hospitalisation for MI at 365 days and a 6% decrease (p = .03) at day 30 for re-vascularisation. Conclusions: We report a strong association between kidney function and all-cause mortality at both early, mid- and long-term follow-up in patients undergoing coronary angiography and intervention, with eGFR significantly associated with MI-related mortality after one month of follow-up. Kidney function was also shown to be associated with risk for re-vascularisation at one month, indicating mostly procedural-related risk and with new MI at mid-term follow-up. Further research is warranted to explore the mechanisms linking kidney function and cardiovascular disease to improve both the short- and long-term care of these patients.
ISSN: 1784-973X
DOI: 10.1080/00015385.2017.1395546
Rights: © Belgian Society of Cardiology
Type: Article
Affiliation : Cyprus University of Technology 
Danderyd University Hospital 
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