Please use this identifier to cite or link to this item: https://ktisis.cut.ac.cy/handle/10488/11850
Title: The effect of the use of thyme honey in minimizing radiation - induced oral mucositis in head and neck cancer patients: a randomized controlled trial
Authors: Charalambous, Melanie 
Raftopoulos, Vasilios 
Paikousis, Lefkios 
Katodritis, Nicos 
Lambrinou, Ekaterini 
Vomvas, Dimitrios 
Georgiou, Morpho 
Charalambous, Andreas 
Keywords: Head and neck cancer;Honey;Management;Radiation-induced mucositis
Category: Clinical Medicine
Field: Medical and Health Sciences
Issue Date: Jun-2018
Publisher: Churchill Livingstone
Source: European Journal of Oncology, 2018, Nursing Volume 34, Pages 89-97
DOI: https://doi.org/10.1016/j.ejon.2018.04.003
Abstract: Purpose: Radiation-induced oral mucositis is one of the main side effects during and after the treatment of head and neck cancer patients. The study was designed to provide evidence on the effectiveness of thyme honey on oral mucositis management. Methods: This was a randomised controlled trial (RCT) with 72 head and neck cancer patients who were divided either to the intervention group (thyme honey rinses) or to the control group (saline rinses). Oral mucositis was assessed according to the Radiation Therapy Oncology Group (RTOC criteria), and assessments were performed weekly starting at the 4th week of the radiotherapy for seven weeks and repeated once 6 months later. Additionally, the Oral Mucositis Weekly Questionnaire (OMWQ) was given at 4th week of radiotherapy, 1 month after the completion of radiotherapy and 6 months later. The ClinicalTrials.gov Identifier for this study is NCT01465308. This paper reports on the findings regarding thyme honey's effectiveness on oral mucositis. Results: Generalized estimating equations revealed that patients in the intervention group were graded lower in the objective assessment of oral mucositis (p < 0,001), maintained their body weight (p < 0,001) and showed an improvement in their global health (p = 0.001) compared to the control group. Quality of life of the patients in the same group was also statistically significantly higher than that of the patients of the control group (p < 0,001). Conclusion: The study provided evidence on the positive effect of thyme honey on the management of radiation-induced oral mucositis and quality of life in head and neck cancer patients.
URI: http://ktisis.cut.ac.cy/handle/10488/11850
ISSN: 14623889
Rights: © Elsevier Ltd
Type: Article
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