Please use this identifier to cite or link to this item: https://ktisis.cut.ac.cy/handle/10488/11021
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dc.contributor.authorMakris, Konstantinos C.-
dc.contributor.authorVoniatis, Michael-
dc.date.accessioned2018-05-04T11:41:39Z-
dc.date.available2018-05-04T11:41:39Z-
dc.date.issued2018-04-01-
dc.identifier.citationEuropean Journal of Public Health, 2018, Volume 28, Issue 2, Pages 338–343en_US
dc.identifier.issn1464-360X-
dc.identifier.urihttp://ktisis.cut.ac.cy/handle/10488/11021-
dc.description.abstractBackground: The health risks associated with dichloromethane (DCM) for the general population living near industrial activities have not yet been quantified, primarily due to lack of epidemiological datasets. In the absence of such human data, we undertook a cancer cluster investigation in Cyprus around a historically using DCM plant producing shoe soles that were globally exported. We designed the methodology to investigate the possible existence of a cancer cluster in the area around the factory (point zero) and within a radius of 500 meters. Methods: A retrospective comparative population study was designed using a group of cancer patients living or working in the chosen geographical area around the factory. Results: Mean stack emissions of DCM of 88 mg/Nm(3) and flow rates of 850 g/h exceeded the permissible DCM limits established for industrial zones. Brain and central nervous system (CNS) cancer incidence rates showed significant (P < 0.001) increase in the study area around the plant when compared with those observed in other areas of Cyprus. Calculated standardized incidence ratios for brain/CNS after adjusting for the age at diagnosis ranged from 11.3-25.7 [mean 6.5 (3.02 : 12.3)] for the study area. Conclusions: We showed the association between chronic, unintentional DCM exposures and brain/CNS cancer cases for the general population located in a residential area being in close proximity with a plant historically emitting DCM.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.rights© The Author 2017en_US
dc.subjectBrain tumorsen_US
dc.subjectCanceren_US
dc.subjectCentral nervous systemen_US
dc.subjectCentral nervous system neoplasmsen_US
dc.subjectExposureen_US
dc.subjectCyprusen_US
dc.subjectGeographic areaen_US
dc.subjectMethylene chlorideen_US
dc.subjectPlantsen_US
dc.subjectRadiusen_US
dc.subjectShoesen_US
dc.subjectBrain diagnosisen_US
dc.subjectFluid flowen_US
dc.subjectDatasetsen_US
dc.titleBrain cancer cluster investigation around a factory emitting dichloromethaneen_US
dc.typeArticleen_US
dc.doihttps://doi.org/10.1093/eurpub/ckx170en_US
dc.collaborationCyprus University of Technologyen_US
dc.collaborationMinistry of Labour, Welfare and Social Insuranceen_US
dc.subject.categoryClinical Medicineen_US
dc.journalsSubscription Journalen_US
dc.countryCyprusen_US
dc.subject.fieldMedical and Health Sciencesen_US
dc.publicationPeer Revieweden_US
cut.common.academicyear2017-2018en_US
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.languageiso639-1other-
crisitem.author.deptCyprus International Institute for Environmental and Public Health-
crisitem.author.facultyFaculty of Health Sciences-
crisitem.author.orcid0000-0001-5251-8619-
crisitem.author.parentorgFaculty of Health Sciences-
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