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Title: Cohort-friendly protocol for a sensitive and fast method for trihalomethanes in urine using gas chromatography—Triple quadrupole mass spectrometry
Authors: Charisiadis, Pantelis 
Makris, Konstantinos C. 
Keywords: Biobanks;Biomarkers;Chlorine;Cohorts;Disinfection by products;Exposure
Category: Basic Medicine
Field: Medical and Health Sciences
Issue Date: 1-Jan-2018
Publisher: Elsevier B.V.
Source: Journal of Chromatography B, 2018, Volume 1072, Pages 336-340
Abstract: A cohort-friendly biomonitoring protocol has been developed for measuring biomarkers of exposure to disinfection by-products (trihalomethanes, THM) in urine using small initial volume (3 mL) and short analysis time (∼10 min) that facilitates the throughput of a large number of samples. The objective of this study was to optimise a cohort-friendly biomonitoring protocol for the determination of four THM analytes in human urine using gas chromatography coupled with triple quadrupole mass spectrometry (GC-QqQ-MS/MS). The proposed methodology will facilitate the inclusion of such urinary THM measurements into large population health studies.
ISSN: 15700232
Rights: © 2017 Elsevier B.V.
Type: Article
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