Please use this identifier to cite or link to this item: https://ktisis.cut.ac.cy/handle/10488/10971
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dc.contributor.authorParmaki, Stella-
dc.contributor.authorVyrides, Ioannis-
dc.contributor.authorVasquez, Marlen-
dc.contributor.authorHartman, Viki-
dc.contributor.authorZacharia, Irene-
dc.contributor.authorHadjiadamou, Ioanna-
dc.contributor.authorBarbeitos, Catarina B.M-
dc.contributor.authorFerreira, Frederico C.-
dc.contributor.authorAfonso, Carlos A.M.-
dc.contributor.authorDrouza, Chryssoula-
dc.contributor.authorKoutinas, Michalis-
dc.date.accessioned2018-04-27T06:27:38Z-
dc.date.available2018-04-27T06:27:38Z-
dc.date.issued2018-02-
dc.identifier.citationChemosphere, 2018, Volume 193, Pages 50-59en_US
dc.identifier.issn0045-6535-
dc.identifier.urihttp://ktisis.cut.ac.cy/handle/10488/10971-
dc.description.abstractThis work explores the potential for development of a lupanine valorization process evaluating different isolated microorganisms for their capacity to metabolize the alkaloid. Ecotoxicological assessment demonstrated that lupanine is toxic for Vibrio fischeri and Daphnia magna exhibiting EC50 values of 89 mg L−1 and 47 mg L−1 respectively, while acting both as growth inhibitor for a monocotyledonous and as promoter for a dicotyledonous plant. Among the eight aerobic and anaerobic strains isolated and identified Rhodococcus rhodochrous LPK211 achieved 81% removal for 1.5 g L−1 lupanine, while no end-products were detected by NMR constituting a promising microorganism for lupanine biodegradation. Moreover, Rhodococcus ruber LPK111 and Rhodococcus sp. LPK311 exhibited 66% and 71% of removal respectively, including potential formation of lupanine N-oxide. Pseudomonas putida LPK411 reached 80% of lupanine removal and generated three fermentation products potentially comprising 17-oxolupanine and lupanine derivatives with open ring structures enabling the development of alkaloid valorization processes.en_US
dc.formatpdfen_US
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofChemosphereen_US
dc.rights© 2017 Elsevier Ltden_US
dc.subjectBioconversionen_US
dc.subjectBiodegradationen_US
dc.subjectLupanineen_US
dc.subjectQuinolizidine alkaloidsen_US
dc.subjectToxicity assessmenten_US
dc.titleBioconversion of alkaloids to high-value chemicals: Comparative analysis of newly isolated lupanine degrading strainsen_US
dc.typeArticleen_US
dc.doihttps://doi.org/10.1016/j.chemosphere.2017.10.165en_US
dc.collaborationCyprus University of Technologyen_US
dc.collaborationUniversity of Cyprusen_US
dc.collaborationUniversidade de Lisboaen_US
dc.subject.categoryChemical Sciencesen_US
dc.journalsHybrid Open Access Journalen_US
dc.countryCyprusen_US
dc.countryPortugalen_US
dc.subject.fieldNatural Sciencesen_US
dc.publicationPeer Revieweden_US
dc.identifier.doi10.1016/j.chemosphere.2017.10.165en_US
cut.common.academicyear2017-2018en_US
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1other-
crisitem.journal.journalissn0045-6535-
crisitem.journal.publisherElsevier-
crisitem.author.deptDepartment of Environmental Science and Technology-
crisitem.author.deptDepartment of Environmental Science and Technology-
crisitem.author.deptDepartment of Agricultural Sciences, Biotechnology and Food Science-
crisitem.author.facultyFaculty of Geotechnical Sciences and Environmental Management-
crisitem.author.facultyFaculty of Geotechnical Sciences and Environmental Management-
crisitem.author.facultyFaculty of Geotechnical Sciences and Environmental Management-
crisitem.author.orcid0000-0001-8316-4577-
crisitem.author.orcid0000-0002-9849-5616-
crisitem.author.orcid0000-0002-2630-4323-
crisitem.author.parentorgFaculty of Geotechnical Sciences and Environmental Management-
crisitem.author.parentorgFaculty of Geotechnical Sciences and Environmental Management-
crisitem.author.parentorgFaculty of Geotechnical Sciences and Environmental Management-
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