Please use this identifier to cite or link to this item: https://ktisis.cut.ac.cy/handle/10488/10044
Title: The effectiveness of thyme honey for the management of treatment-induced xerostomia in head and neck cancer patients: A feasibility randomized control trial
Authors: Charalambous, Andreas 
Lambrinou, Ekaterini 
Katodritis, Nicos 
Vomvas, Dimitrios 
Raftopoulos, Vasilios 
Georgiou, Morpho 
Paikousis, Lefkios 
Charalambous, Melanie 
Keywords: Head and neck cancer;Nursing;Thyme honey;Treatment-induced xerostomia
Category: Health Sciences
Field: Medical and Health Sciences
Issue Date: 1-Apr-2017
Publisher: Churchill Livingstone
Source: European Journal of Oncology Nursing, 2017, vol. 27, pp. 1-8
Journal: European Journal of Oncology Nursing 
Abstract: Purpose Radiation-induced xerostomia is one of the most common side effects that head and neck cancer patients experience during and after treatment. Despite the various methods for the prevention and treatment of radiation-induced xerostomia, it remains highly prevalent among patients treated for head and neck cancers negatively influencing their lives. The purpose of this study was to evaluate the effectiveness of thyme honey as a means for managing radiation-induced xerostomia. Method This was a parallel randomised controlled trial with two equal arms, the experimental arm (thyme honey) and the control arm (saline). 72 head and neck cancer patients receiving radiotherapy or/and chemotherapy or/and surgery were recruited in a specialised cancer centre. Patients in both arms followed the same administration protocol with thyme honey and saline respectively. Identical assessments at baseline, 1 month and 6 months following completion of the intervention were performed in both arms including the National Cancer Institute (NCI) xerostomia scale and the Xerostomia Questionnaire (XQ) additionally to weekly oral clinical assessments. The ClinicalTrials.gov Identifier for this study is NCT01465308. Results Linear Mixed Models revealed the statistically significant effect of the intervention on xerostomia (F = 8.474 p < 0.001) and overall quality of life (F = 13.158 p < 0.001). Moreover, Generalised Estimating Equations revealed a statistically significant effect on strong and unbearable pain (F = 10.524 p < 0.001) and dysphagia (F = 4.525 p = 0.033). Conclusion The study has demonstrated the safety and efficacy findings of Thyme honey in head and neck cancer patients for the management of treatment induced xerostomia.
ISSN: 1462-3889
DOI: 10.1016/j.ejon.2017.01.001
Collaboration : Cyprus University of Technology
Bank of Cyprus Group Oncology Centre
Improvast
University of Turku
Ministry of Health
Rights: © Elsevier
Type: Article
Appears in Collections:Άρθρα/Articles

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