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Title: Which brainstem cells generate the respiration cycles?
Authors: Irvine, A.W. 
Tsechpenakis, Gabriel 
Chatzis, Sotirios P. 
Irvine, A.W. 
Tsechpenakis, Gabriel 
Keywords: Diagnostic imaging;Multiphoton processes;Photons;Neurons;Respiration;Cells
Issue Date: 2010
Publisher: IEEE Xplore
Source: IEEE international symposium on biomedical imaging: from nano to macro, 2010, Pages 65-68
Abstract: We make a major step towards answering the question posed in the title, using as model the mouse foetus in its 17-19 embryonic days. We use (a) 2-photon microscopy to image the brainstem cell activity ([Ca2+]) in the pre-Boetzinger complex, and (b) electrical recordings from the phrenic nerve, which indicate the diaphragm contraction during inspiration. We classify the brainstem regions (individual cells or groups of cells) into 'active' and 'inactive', based on whether they contribute or not to the individual electrical signal peaks. As features, we use the Continuous Wavelet Transform-based Semblance responses, for comparing non-periodic and/or periodic-like signals. We use our novel Generative Mixture Model (GMM) possibilistic clustering to obtain the desired classes robustly. This way, we model the inspiration control as a physiological process, which is a crucial step towards understanding how the living brain controls breathing
ISBN: 978-1-4244-4125-9 (print)
ISSN: 978-1-4244-4126-6 (online)
DOI: 10.1109/ISBI.2010.5490412
Rights: © 2010 IEEE
Type: Book Chapter
Appears in Collections:Κεφάλαια βιβλίων/Book chapters

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