Please use this identifier to cite or link to this item: http://ktisis.cut.ac.cy/handle/10488/6974
Title: Outbreak of infections due to kpc-2-producing klebsiella pneumoniae in a hospital in Crete (Greece)
Authors: Maragos, Antonios
Maltezou, Helena C.
Raftopoulos, Vasilios 
Keywords: Klebsiella pneumoniae
Resistance
Beta lactamases
Issue Date: 2009
Publisher: Elsevier
Source: Journal of Infection, 2009, Volume 58, Issue 3, Pages 213-219
Abstract: Starting in May 2007, an ongoing outbreak of infections due to carbapenem resistant KPC-2-producing Klebsiella pneumoniae occurred in a tertiary care hospital in Crete (Greece). The outbreak involved 22 patients, none of whom had travelled in a country with known high prevalence of such isolates. KPC-producing K. pneumoniae strains were mainly isolated from patients admitted in the Intensive Care Unit, on mechanical ventilation, with prolonged hospitalization, prolonged administration of antibiotics, and prolonged administration of carbapenems. Clinical diagnoses were: pneumonia (62% of cases), surgical site infection (19%), bacteremia (9.5%), urinary tract infection (4.7%), and peritonitis (4.7%). Overall, 61 KPC-producing K. pneumoniae isolates were recovered, mainly from the respiratory tract (59.1%), catheter tip (22.7%), surgical site (18.2%), and blood (18.2%). Among 16 patients for whom therapeutic data were available, 14 (87.5%) were treated with a combination of colistin and/or tigecycline and/or garamycin. Clinical failure was noted in 22.2% of 18 patients available for assessment of clinical outcome, and microbiologic failure in 87.5% of 8 patients available for assessment of microbiologic outcome. In conclusion, an outbreak of KPC-producing K. pneumoniae infections has occurred in a tertiary care hospital in Greece, with significant associated morbidity and mortality. Prospective studies are required to evaluate the available therapeutic options for these infections. Our efforts should focus on rational use of available antibiotics, enhancement of infection control measures, and implementation of active antibiotic resistance surveillance.
URI: http://ktisis.cut.ac.cy/handle/10488/6974
ISSN: 01634453
DOI: 10.1016/j.jinf.2009.01.010
Rights: © 2009 The British Infection Society.
Appears in Collections:Άρθρα/Articles

Show full item record

SCOPUSTM   
Citations 5

99
checked on Jun 26, 2017

WEB OF SCIENCETM
Citations 5

83
checked on Jun 26, 2017

Page view(s) 50

20
Last Week
6
Last month
3
checked on Jun 27, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.