Please use this identifier to cite or link to this item: http://ktisis.cut.ac.cy/handle/10488/6396
Title: Synthesis, solution, and structural characterization of tetrahydrofuranyl-2,2-bisphosphonic acid disodium salt
Authors: Maltezou, Elena 
Stylianou, Marios 
Roy, Sudeshna 
Keramidas, Anastasios D. 
Drouza, Chryssoula 
Keywords: Diphosphonates;Cancer;Bones;Crystallography
Category: Biological Sciences
Field: Natural Sciences
Issue Date: 2010
Publisher: Hindawi Publishing Corporation
Source: Bioinorganic chemistry and applications, 2010, volume 2010, article number 563875
Abstract: Bisphosphonates are biologically relevant therapeutics for bone disorders and cancer. Reaction of γ-chlorobutyric acid, phosphorus acid, and phosphorus trichloride without the use of solvent gave the tetrahydrofuranyl-2, 2-bisphosphonate sodium salt (Na2H2L). The Na 2H2L was isolated, characterized in solution by 1H, 13C, and 31P NMR spectroscopy and in solid state by single X-Ray crystallography. The crystal structure showed that the Na2H2L forms in the crystal infinite two-dimensional sheets stacked one parallel to the other. A comparison of the chelating properties of H2L2- with similar hydroxyl bisphosphonate ligands shows that the strength of the NaO(furanyl/hydroxyl) bond is directly related to the total charge of the ligand anion
URI: http://ktisis.cut.ac.cy/handle/10488/6396
ISSN: 15653633
DOI: 10.1155/2010/563875
Rights: Copyright © 2010 Elena Maltezou et al
Type: Article
Appears in Collections:Άρθρα/Articles

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