Please use this identifier to cite or link to this item: http://ktisis.cut.ac.cy/handle/10488/4300
Title: Assessment of inbreeding resulting from selection for scrapie resistance: a model for rare sheep breeds
Authors: Brown, Catherine J. 
Orford, Michael R. 
Mavrogenis, Andreas 
Tzamaloukas, Ouranios 
Miltiadou, Despoina 
Keywords: Genetic Diversity
Inbreeding
Rare Breed
Scrapie Resistance
Sheep
Animalia
Ovis aries
Issue Date: 2014
Publisher: British Veterinary Association
Source: Veterinary Record, 2014, Volume 175, Issue 24, Page 624.
Abstract: nbreeding in a small population of Chios sheep undergoing intense selection for the PrP gene was assessed 10 years after the beginning of a scrapie resistance selection programme. Inbreeding in this stock, already under selection for production traits, was analysed by using pedigree records containing 10,492 animals from 1968 to 2008, and also by genotyping 192 individuals with a panel of 15 microsatellites. Genetic markers indicated a loss of heterozygosity (FIS over all loci was 0.059) and allelic diversity (mean effective number of alleles was 3.075±0.275). The annual rate of inbreeding increased significantly after the start of the scrapie resistance programme, ΔF=0.005 compared with ΔF=0.001 before 1999, and was subjected to several genetic bottlenecks, mainly due to the low initial frequency of resistant animals. However, the mean individual inbreeding coefficient estimated from the pedigree - in this closed stock resembling the case of a rare breed - stood at the level of 4.5 per cent, five generations after the implementation of selection for the PrP gene. The inbreeding coefficient estimated by genetic markers was 4.37 per cent, implying that such a marker panel could be a useful and cost-effective tool for estimating inbreeding in unrecorded populations.
URI: http://ktisis.cut.ac.cy/jspui/handle/10488/4300
ISSN: 00424900
DOI: 10.1136/vr.102503
Rights: © Copyright 2014 Elsevier B.V., All rights reserved.
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