Please use this identifier to cite or link to this item: http://ktisis.cut.ac.cy/handle/10488/4144
Title: Association of proinflammatory molecules with apoptotic markers and survival in critically ill multiple organ dysfunction patients
Authors: Papathanassoglou, Elizabeth 
Moynihan, Jan
Dafni, Ourania
Mantzoros, Christos S. 
Ackerman, Michael
Keywords: MODS;Apoptosis;Fas;Cytokines;Nitric oxide;Cortisol;Interleukin-6;Tumor necrosis factor-α
Category: Health Sciences
Field: Medical and Health Sciences
Issue Date: 2003
Publisher: Sage Publications
Source: Biological Research for Nursing, 2003, Volume 5, Number 2, Pages 129-141
Link: http://brn.sagepub.com/content/5/2/129.abstract
Abstract: Recent evidence supports the involvement of apoptosis in multiple organ dysfunction (MODS). The authors examined the hypothesis that nitric oxide (NO), interleukin (IL)-6, tumor necrosis factor (TNF)-α, and cortisol correlate with Fas and Fas ligand (FasL) expression on peripheral blood mononuclear cells and that Fas and FasL, therefore, mediate their association with MODS severity. Thirty-five critically ill adult MODS patients were followed for up to 14 days and were compared to non-MODS matched controls. Fas, FasL, nitrate, cortisol, and IL-6 were elevated in MODS patients (P < 0.05). Nitrate and cortisol correlated with Fas expression (P < 0.05). All factors studied, except for TNF-α, correlated with MODS severity (P< 0.05); however, by multivariate analyses, Fas and FasL were independently associated with severity and survival (P < 0.05). The inflammatory molecules studied may mediate the association of apoptotic constituents with MODS severity and survival only in part.
URI: http://ktisis.cut.ac.cy/handle/10488/4144
ISSN: 1552-4175
Rights: © Sage Publications
Type: Article
Appears in Collections:Άρθρα/Articles

Show full item record

Page view(s)

18
Last Week
0
Last month
0
checked on Nov 23, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.