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Title: The mediterranean dietary pattern and breast cancer risk in Greek-Cypriot women: a case-control study
Authors: Demetriou, Christiana A. 
Hadjisavvas, Andreas 
Loizidou, Maria A 
Loucaides, Giorgos 
Neophytou, Ioanna 
Sieri, Sabina 
Kakouri, Eleni 
Middleton, Nicos 
Vineis, Paolo 
Kyriacou, Kyriacos C. 
Keywords: Prospective cohort;Postmenopausal women;Meat consumption;Vegetables;Adherence;Estrogen;Health;Fruits;Fish;Fat
Category: Health Sciences
Field: Medical and Health Sciences
Issue Date: 23-Mar-2012
Publisher: BioMed Central
Source: BMC Cancer, 2012, Volume 13, Article Number 113
Abstract: Background: Diet has long been suspected to impact on breast cancer risk. In this study we evaluated whether the degree of adherence to a Mediterranean diet pattern modifies breast cancer risk amongst Greek-Cypriot women. Methods: Subjects included 935 cases and 817 controls, all participating in the MASTOS case-control study in Cyprus. The study was approved by the Cyprus National Bioethics Committee. Information on dietary intakes was collected using an interviewer administered 32-item Food Frequency Questionnaire. Information on demographic, anthropometric, lifestyle, and other confounding factors was also collected. Adherence to the Mediterranean Diet pattern was assessed using two a-priory defined diet scores. In addition, dietary patterns specific to our population were derived using Principal Component Analysis (PCA). Logistic regression models were used to assess the association between the dietary patters and breast cancer risk. Results: There was no association with breast cancer risk for either score, however, higher consumptions of vegetables, fish and olive oil, were independently associated with decreased risk. In addition, the PCA derived component which included vegetables, fruit, fish and legumes was shown to significantly reduce risk of breast cancer (ORs across quartiles of increasing levels of consumption: 0.89 95%CI: 0.65-1.22, 0.64 95%CI: 0.47-0.88, 0.67 95%CI: 0.49-0.92, P trend < 0.0001), even after adjustment for relevant confounders. Conclusions: Our results suggest that adherence to a diet pattern rich in vegetables, fish, legumes and olive oil may favorably influence the risk of breast cancer. This study is the first investigation of dietary effects on breast cancer risk in Cyprus, a country whose population has traditionally adhered to the Mediterranean diet.
ISSN: 1471-2407
DOI: 10.1186/1471-2407-12-113
Rights: © 2012 Demetriou et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Type: Article
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