Please use this identifier to cite or link to this item: http://ktisis.cut.ac.cy/handle/10488/3462
Title: Low serum high-density lipoprotein cholesterol in childhood is associated with adolescent asthma
Authors: Yiallouros, Panayiotis K. 
Savva, Savvas C.
Kourides, Yiannis A.
Kolokotroni, Ourania 
Behbod, Behrooz
Zeniou, Maria 
Economou, Mary
Chadjigeorgiou, Charalambos
Lamnisos, Demetris 
Middleton, Nicos 
Milton, Donald Kirby 
Tornaritis, Michael J.
Keywords: Adiposity;Adolescents;Asthma;High-density lipoprotein cholesterol;Physical fitness
Category: Clinical Medicine
Field: Medical and Health Sciences
Issue Date: Mar-2012
Publisher: John Wiley & Sons
Source: Clinical & Experimental Allergy, 2012, Volume 42, Issue 3, Pages 423-432
Abstract: Background Whilst emerging evidence from animal and cell experiments has shown high-density lipoprotein cholesterol to have anti-inflammatory effects consistent with a protective role in asthma, human studies investigating the relationship of high-density lipoprotein cholesterol with asthma have produced conflicting results. Objective To examine the association between serum lipids among Cypriot children aged 11-12 years and prevalence of asthma at age 15-17 years. Methods In 3982 children, we assessed serum lipids, body mass index and maximal oxygen consumption at baseline (2001-2003) and explored associations with respiratory health at follow-up (2007) using multiple logistic regression models. Results Lower levels of high-density lipoprotein cholesterol at age 11-12 years were found in subjects who reported ever asthma (58.2 vs. 60.0 mg/dL, P = 0.005) and active asthma (57.5 vs. 59.9 mg/dL, P = 0.010) in adolescence, in comparison with their respective reference groups. Total cholesterol, low-density lipoprotein and triglycerides had no association with any of the asthma outcomes. In contrast, with estimated odds ratios of 1.89 (95% CI 1.19-3.00) and 1.89 (95% CI 1.02-3.53), ever asthma and active asthma respectively appeared particularly pronounced among those who at baseline had high-density lipoprotein cholesterol <40 mg/dL, even after adjusting for potential confounders including body mass index and maximal oxygen consumption. Conclusions & Clinical Relevance Low-serum high-density lipoprotein cholesterol in childhood is associated with an increased risk for asthma in adolescence, suggesting a potential role of this lipoprotein in the pathogenesis of paediatric asthma.
URI: http://ktisis.cut.ac.cy/handle/10488/3462
ISSN: 0954-7894
DOI: 10.1111/j.1365-2222.2011.03940.x
Rights: Copyright © 1999-2014 John Wiley & Sons, Inc. All Rights Reserved.
Type: Article
Appears in Collections:Άρθρα/Articles

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