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|Title:||Low serum high-density lipoprotein cholesterol in childhood is associated with adolescent asthma||Authors:||Yiallouros, Panayiotis K.
Savva, Savvas C.
Kourides, Yiannis A.
Milton, Donald Kirby
Tornaritis, Michael J.
|Keywords:||Adiposity;Adolescents;Asthma;High-density lipoprotein cholesterol;Physical fitness||Category:||Clinical Medicine||Field:||Medical and Health Sciences||Issue Date:||Mar-2012||Publisher:||John Wiley & Sons||Source:||Clinical & Experimental Allergy, 2012, Volume 42, Issue 3, Pages 423-432||Abstract:||Background Whilst emerging evidence from animal and cell experiments has shown high-density lipoprotein cholesterol to have anti-inflammatory effects consistent with a protective role in asthma, human studies investigating the relationship of high-density lipoprotein cholesterol with asthma have produced conflicting results. Objective To examine the association between serum lipids among Cypriot children aged 11-12 years and prevalence of asthma at age 15-17 years. Methods In 3982 children, we assessed serum lipids, body mass index and maximal oxygen consumption at baseline (2001-2003) and explored associations with respiratory health at follow-up (2007) using multiple logistic regression models. Results Lower levels of high-density lipoprotein cholesterol at age 11-12 years were found in subjects who reported ever asthma (58.2 vs. 60.0 mg/dL, P = 0.005) and active asthma (57.5 vs. 59.9 mg/dL, P = 0.010) in adolescence, in comparison with their respective reference groups. Total cholesterol, low-density lipoprotein and triglycerides had no association with any of the asthma outcomes. In contrast, with estimated odds ratios of 1.89 (95% CI 1.19-3.00) and 1.89 (95% CI 1.02-3.53), ever asthma and active asthma respectively appeared particularly pronounced among those who at baseline had high-density lipoprotein cholesterol <40 mg/dL, even after adjusting for potential confounders including body mass index and maximal oxygen consumption. Conclusions & Clinical Relevance Low-serum high-density lipoprotein cholesterol in childhood is associated with an increased risk for asthma in adolescence, suggesting a potential role of this lipoprotein in the pathogenesis of paediatric asthma.||URI:||http://ktisis.cut.ac.cy/handle/10488/3462||ISSN:||0954-7894||DOI:||10.1111/j.1365-2222.2011.03940.x||Rights:||Copyright © 1999-2014 John Wiley & Sons, Inc. All Rights Reserved.||Type:||Article|
|Appears in Collections:||Άρθρα/Articles|
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