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Title: Possible obesogenic effects of bisphenols accumulation in the human brain
Authors: Charisiadis, Pantelis 
Andrianou, Xanthi 
Van Der Meer, Thomas P. 
Den Dunnen, Wilfred F. A. 
Swaab, Dick F. 
Wolffenbuttel, Bruce H. R. 
Makris, Konstantinos C. 
Van Vliet-Ostaptchouk, Jana V. 
Keywords: Bisphenol A;Bisphenol F;Chlorinated BPA;Bisphenols
Category: Basic Medicine
Field: Medical and Health Sciences
Issue Date: 29-May-2018
Publisher: Nature Publishing Group
Source: Scientific Reports, 2018, Volume 8, Issue 1, Article number 8186
Abstract: Evidence of bisphenols’ obesogenic efects on humans is mixed and inconsistent. We aimed to explore the presence of bisphenol A (BPA), bisphenol F (BPF) and chlorinated BPA (ClBPA), collectively called the bisphenols, in diferent brain regions and their association with obesity using post-mortem hypothalamic and white matter brain material from twelve pairs of obese (body mass index (BMI) >30kg/m2) and normal-weight individuals (BMI <25kg/m2). Mean ratios of hypothalamus:white matter for BPA, BPF and ClBPA were 1.5, 0.92, 0.95, respectively, suggesting no preferential accumulation of the bisphenols in the grey matter (hypothalamic) or white matter-enriched brain areas. We observed diferences in hypothalamic concentrations among the bisphenols, with highest median level detected for ClBPA (median: 2.4ng/g), followed by BPF (2.2ng/g) and BPA (1.2ng/g); similar ranking was observed for the white matter samples (median for: ClBPA-2.5ng/g, BPF-2.3ng/g, and BPA1.0ng/g). Furthermore, all bisphenol concentrations, except for white-matter BPF were associated with obesity (p<0.05). This is the frst study reporting the presence of bisphenols in two distinct regions of the human brain. Bisphenols accumulation in the white matter-enriched brain tissue could signify that they are able to cross the blood-brain barrier.
ISSN: 29844501
Rights: © The Author(s) 2018
Type: Article
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