Please use this identifier to cite or link to this item: http://ktisis.cut.ac.cy/handle/10488/10518
Title: Distribution of non-persistent endocrine disruptors in two different regions of the human brain
Authors: Van Der Meer, Thomas P. 
Artacho-Cordón, Francisco 
Swaab, Dick F. 
Struik, Dicky 
Makris, Konstantinos C. 
Wolffenbuttel, Bruce H. R. 
Frederiksen, Hanne 
Van Vliet-Ostaptchouk, Jana V. 
Keywords: Obesity;Hypothalamus;Brain;Parabens;Phenols;Methylparaben;Bisphenol-A
Category: Earth and Related Environmental Sciences
Field: Natural Sciences
Issue Date: 13-Sep-2017
Publisher: MDPI AG
Source: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, Volume: 14, Issue: 9, Article Number: 1059, Published: SEP 2017
metadata.dc.doi: http://dx.doi.org/10.3390/ijerph14091059
Journal: International Journal of Environmental Research and Public Health
Abstract: Non-persistent endocrine disrupting chemicals (npEDCs) can affect multiple organs and systems in the body. Whether npEDCs can accumulate in the human brain is largely unknown. The major aim of this pilot study was to examine the presence of environmental phenols and parabens in two distinct brain regions: the hypothalamus and white-matter tissue. In addition, a potential association between these npEDCs concentrations and obesity was investigated. Post-mortem brain material was obtained from 24 individuals, made up of 12 obese and 12 normal-weight subjects (defined as body mass index (BMI) > 30 and BMI < 25 kg/m(2), respectively). Nine phenols and seven parabens were measured by isotope dilution TurboFlow-LC-MS/MS. In the hypothalamus, seven suspect npEDCs (bisphenol A, triclosan, triclocarban and methyl-, ethyl-, n-propyl-, and benzyl paraben) were detected, while five npEDCs (bisphenol A, benzophenone-3, triclocarban, methyl-, and n-propyl paraben) were found in the white-matter brain tissue. We observed higher levels of methylparaben (MeP) in the hypothalamic tissue of obese subjects as compared to controls (p = 0.008). Our findings indicate that some suspected npEDCs are able to cross the blood-brain barrier. Whether the presence of npEDCs can adversely affect brain function and to which extent the detected concentrations are physiologically relevant needs to be further investigated.
URI: http://ktisis.cut.ac.cy/handle/10488/10518
ISSN: 1660-4601
Rights: © 2017 by the authors.
Type: Article
Appears in Collections:Άρθρα/Articles

Files in This Item:
File Description SizeFormat 
Makris.pdf171.42 kBAdobe PDFView/Open
Show full item record

Page view(s)

11
Last Week
2
Last month
checked on Dec 13, 2017

Download(s) 50

2
checked on Dec 13, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.