Please use this identifier to cite or link to this item: http://ktisis.cut.ac.cy/handle/10488/1016
Title: Analysis of PrP genotypes in relation to reproductive and production traits in Chios sheep
Authors: Ioannides, Ioannis M. 
Mavrogenis, Andreas 
Papachristoforou, Christakis 
Keywords: Scrapie
Sheep
Genotypes
Production traits
Issue Date: 2009
Publisher: Elsevier B.V.
Source: Livestock Science. Volume 122, Issues 2-3, June 2009, Pages 296-301
Abstract: The study describes the changes with time in gene and genotype frequencies of a closed Chios herd. Genomic DNA was isolated and purified from peripheral blood leucocytes using standard procedures. The identification of the allelic variants present in the DNA samples, was performed in a simple multiplex PCR reaction and melting curve analysis of the PrP gene. Only ARR/ARR female genotypes were kept for breeding, and only males of the same genotype were used following year 2 of the study. As a result of planned individual matings and selection, the susceptible ARQ/ARQ genotype was eliminated from the flock in 4 years. The gene frequency of the R allele from a low 0.056 at year 1 reached a high 0.911 at year 6 of the study. Data from first lactation ewes of known genotypes were used to examine possible associations between PrP genotypes and ewe reproductive (litter size at birth and at weaning) and production traits (litter weight at birth and at weaning and 60-day milk yield after weaning). No effects of the sire genotype (ARR/ARR and ARR/ARQ) were found for any of the traits studied. The ewe genotype was associated with performance for reproductive traits but not with total weight of lamb output at birth or at weaning. ARR/ARR ewes had a higher litter size at birth (2.09) compared to ARQ/ARQ ewes (1.79) and higher litter size at weaning (1.84) compared to ARR/ARQ ewes (1.59). 60-day milk yield after weaning was not influenced by genotype (114.8, 105.8 and 114.8 kg for ARR/ARR, ARR/ARQ and ARQ/ARQ genotypes, respectively). Birth weight and 98-day weight were not influenced by the lamb genotype. ARQ/ARQ lambs were slightly heavier (P < 0.05) than ARR/ARR lambs at weaning as a result of faster pre-weaning growth. Post weaning growth was similar for the homozygous genotypes.
URI: http://ktisis.cut.ac.cy/handle/10488/1016
ISSN: 1871-1413
DOI: 10.1016/j.livsci.2008.09.022
Rights: © 2008 Elsevier B.V.
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