Please use this identifier to cite or link to this item: http://ktisis.cut.ac.cy/handle/10488/10046
Title: Partitioning of red blood cell aggregates in bifurcating microscale flows
Authors: Kaliviotis, Efstathios 
Sherwood, Joseph M. 
Balabani, Stavroula 
Keywords: Cell suspension
Vascular resistance
Chemical binding
Circulation
Issue Date: 17-Mar-2017
Publisher: Nature Publishing Group
Source: Scientific Reports, 2017, Volume 7, Article number 44563
Abstract: Microvascular flows are often considered to be free of red blood cell aggregates, however, recent studies have demonstrated that aggregates are present throughout the microvasculature, affecting cell distribution and blood perfusion. This work reports on the spatial distribution of red blood cell aggregates in a T-shaped bifurcation on the scale of a large microvessel. Non-aggregating and aggregating human red blood cell suspensions were studied for a range of flow splits in the daughter branches of the bifurcation. Aggregate sizes were determined using image processing. The mean aggregate size was marginally increased in the daughter branches for a range of flow rates, mainly due to the lower shear conditions and the close cell and aggregate proximity therein. A counterintuitive decrease in the mean aggregate size was apparent in the lower flow rate branches. This was attributed to the existence of regions depleted by aggregates of certain sizes in the parent branch, and to the change in the exact flow split location in the T-junction with flow ratio. The findings of the present investigation may have significant implications for microvascular flows and may help explain why the effects of physiological RBC aggregation are not deleterious in terms of in vivo vascular resistance.
URI: http://ktisis.cut.ac.cy/handle/10488/10046
ISSN: 20452322
Rights: © The Author(s) 2017.
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